Neurochemical alterations of the entorhinal cortex in amnestic mild cognitive impairment (aMCI): A three-year follow-up study

Sang Won Seo, Jung Hee Lee, Sung Man Jang, Sung Tae Kim, Juhee Chin, Geon Ha Kim, Jong Hun Kim, Jee Hoon Roh, Min Jeong Kim, Sook Hui Kim, Duk L. Na

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


The neurochemical alterations in the entorhinal cortex have not yet been measured, even though the entorhinal cortex is the earliest involved brain region in aMCI. In this study, we investigated whether brain regions including the entorhinal cortex would show early involvement of neurochemical abnormalities in aMCI, and whether magnetic resonance spectroscopy (MRS) abnormalities might be a predictive marker of conversion of aMCI to Alzheimer's disease (AD). MRS was performed on 13 aMCI patients and 11 patients with no cognitive impairment (NCI). Localizing voxels were placed within the entorhinal cortex, hippocampus, posterior cingulate gyrus, and occipital white matter in the dominant hemisphere. N-acetyl aspartate/creatinine (NAA/Cr) ratios in the entorhinal cortex were significantly lower in aMCI patients than in NCI subjects. After a three-year follow-up, seven aMCI patients converted to AD and six remained stable. Baseline NAA/Cr ratios of entorhinal cortex were decreased in converters, compared to NCI. Our study suggested the entorhinal cortex is the earliest site that is subject to neurochemical alteration in aMCI patients, and baseline MRS metabolite ratios in the entorhinal cortex can be a marker for predicting conversion of aMCI to AD.

Original languageEnglish
Pages (from-to)192-196
Number of pages5
JournalArchives of Gerontology and Geriatrics
Issue number1
Publication statusPublished - 2012 Jan
Externally publishedYes

Bibliographical note

Funding Information:
This study was supported by a grant from the Korean Healthcare Technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea (A080855).


  • Alzheimer disease
  • Amnestic MCI
  • Conversion
  • Entorhinal cortex
  • Magnetic resonance spectroscopy

ASJC Scopus subject areas

  • Health(social science)
  • Ageing
  • Gerontology
  • Geriatrics and Gerontology


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