Neuroimaging in randomized, multi-center clinical trials of endovascular treatment for acute ischemic stroke: A systematic review

Chong Hyun Suh, Seung Chai Jung, Byungjun Kim, Se Jin Cho, Dong Cheol Woo, Woo Yong Oh, Jong Gu Lee, Kyung Won Kim

    Research output: Contribution to journalReview articlepeer-review

    4 Citations (Scopus)


    Appropriate use and analysis of neuroimaging techniques is an inevitable aspect of clinical trials for patients with acute ischemic stroke. Neuroimaging examinations were recently used to define the core eligibility criteria and outcomes in acute ischemic stroke research. Recent clinical trials for endovascular treatment in acute ischemic stroke have also demonstrated the efficacy or safety of endovascular treatment using various imaging modalities as well as clinical indices. Furthermore, independent imaging reviews and imaging core laboratory assessments are essential to manage and analyze imaging data in order to enhance the reliability of the outcomes. Therefore, we systematically reviewed the use of neuroimaging in recent randomized clinical trials for endovascular treatment of acute ischemic stroke in order to provide a thorough summary, which would serve as a resource guiding the use of appropriate imaging protocols and analyses in future clinical trials for acute ischemic stroke. This review will help researchers select appropriate imaging biomarkers among the various imaging protocols available and apply the selected type of imaging examination for each study in accordance with the academic purpose.

    Original languageEnglish
    Pages (from-to)42-57
    Number of pages16
    JournalKorean journal of radiology
    Issue number1
    Publication statusPublished - 2020 Jan

    Bibliographical note

    Funding Information:
    Received June 4, 2019; accepted after revision October 1, 2019. This study was supported by a grant from the Ministry of Food and Drug Safety in 2018 (No. 18182MFDS402). Corresponding author: Seung Chai Jung, MD, PhD, Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea. • Tel: (822) 3010-3949 • Fax: (822) 476-4719 • E-mail: This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

    Publisher Copyright:
    © 2020 The Korean Society of Radiology.


    • Acute ischemic stroke
    • Clinical trials
    • Endovascular treatment
    • Neuroimaging
    • Systematic review

    ASJC Scopus subject areas

    • Radiology Nuclear Medicine and imaging


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