Neuroprotective constituents from the fruits of Maclura tricuspidata

Nguyen Tuan Hiep; Jaeyoung Kwon; Dong Woo Kim; Sungeun Hong; Yuanqiang Guo; Bang Yeon Hwang; Nahyun Kim; Woongchon Mar; Dongho Lee

doi:10.1016/j.tet.2017.03.064

Neuroprotective constituents from the fruits of Maclura tricuspidata

Nguyen Tuan Hiep, Jaeyoung Kwon, Dong Woo Kim, Sungeun Hong, Yuanqiang Guo, Bang Yeon Hwang, Nahyun Kim, Woongchon Mar, Dongho Lee

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Cudraisoflavone L − T (1–11), cudradihydrochalcone A (12), and cudrabibenzyl A (13), together with 41 known constituents, were isolated from the fruits of Maclura tricuspidata (formerly known as Cudrania tricuspidata). Their structures were determined by spectroscopic and chemical methods including electronic circular dichroism. All isolated compounds were evaluated for their neuroprotective effects against 6-hydroxydopamine (6-OHDA)-induced cell death in human neuroblastoma SH-SY5Y cells, of these six compounds exhibited activities with EC₅₀ values of 4.5–18.6 μM. Furthermore, the neuroprotective effects against oxygen glucose deprivation (OGD)-induced cell death of all isolated constituents, together with 37 previously reported isoflavones were evaluated. Four compounds showed neuroprotective activities with EC₅₀ values of 3.5–11.9 μM.

Original language	English
Pages (from-to)	2747-2759
Number of pages	13
Journal	Tetrahedron
Volume	73
Issue number	19
DOIs	https://doi.org/10.1016/j.tet.2017.03.064
Publication status	Published - 2017

Bibliographical note

Funding Information:
This work was supported by grants from the National Research Foundation of Korea (NRF-2015R1D1A1A01060321and NRF-2015R1D1A1A01056603) and BK21 plus program in 2015 year through NRF funded by the Ministry of Education of Korea.

Publisher Copyright:
© 2017 Elsevier Ltd

Keywords

Circular dichroism
Cudrania tricuspidata
Maclura tricuspidata
Neuroprotective activity
Snatzke's method

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tet.2017.03.064

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title = "Neuroprotective constituents from the fruits of Maclura tricuspidata",

abstract = "Cudraisoflavone L − T (1–11), cudradihydrochalcone A (12), and cudrabibenzyl A (13), together with 41 known constituents, were isolated from the fruits of Maclura tricuspidata (formerly known as Cudrania tricuspidata). Their structures were determined by spectroscopic and chemical methods including electronic circular dichroism. All isolated compounds were evaluated for their neuroprotective effects against 6-hydroxydopamine (6-OHDA)-induced cell death in human neuroblastoma SH-SY5Y cells, of these six compounds exhibited activities with EC50 values of 4.5–18.6 μM. Furthermore, the neuroprotective effects against oxygen glucose deprivation (OGD)-induced cell death of all isolated constituents, together with 37 previously reported isoflavones were evaluated. Four compounds showed neuroprotective activities with EC50 values of 3.5–11.9 μM.",

keywords = "Circular dichroism, Cudrania tricuspidata, Maclura tricuspidata, Neuroprotective activity, Snatzke's method",

author = "Hiep, {Nguyen Tuan} and Jaeyoung Kwon and Kim, {Dong Woo} and Sungeun Hong and Yuanqiang Guo and Hwang, {Bang Yeon} and Nahyun Kim and Woongchon Mar and Dongho Lee",

note = "Funding Information: This work was supported by grants from the National Research Foundation of Korea (NRF-2015R1D1A1A01060321and NRF-2015R1D1A1A01056603) and BK21 plus program in 2015 year through NRF funded by the Ministry of Education of Korea. Publisher Copyright: {\textcopyright} 2017 Elsevier Ltd",

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doi = "10.1016/j.tet.2017.03.064",

language = "English",

volume = "73",

pages = "2747--2759",

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AU - Hiep, Nguyen Tuan

AU - Kwon, Jaeyoung

AU - Kim, Dong Woo

AU - Hong, Sungeun

AU - Guo, Yuanqiang

AU - Hwang, Bang Yeon

AU - Kim, Nahyun

AU - Mar, Woongchon

AU - Lee, Dongho

N1 - Funding Information: This work was supported by grants from the National Research Foundation of Korea (NRF-2015R1D1A1A01060321and NRF-2015R1D1A1A01056603) and BK21 plus program in 2015 year through NRF funded by the Ministry of Education of Korea. Publisher Copyright: © 2017 Elsevier Ltd

PY - 2017

Y1 - 2017

N2 - Cudraisoflavone L − T (1–11), cudradihydrochalcone A (12), and cudrabibenzyl A (13), together with 41 known constituents, were isolated from the fruits of Maclura tricuspidata (formerly known as Cudrania tricuspidata). Their structures were determined by spectroscopic and chemical methods including electronic circular dichroism. All isolated compounds were evaluated for their neuroprotective effects against 6-hydroxydopamine (6-OHDA)-induced cell death in human neuroblastoma SH-SY5Y cells, of these six compounds exhibited activities with EC50 values of 4.5–18.6 μM. Furthermore, the neuroprotective effects against oxygen glucose deprivation (OGD)-induced cell death of all isolated constituents, together with 37 previously reported isoflavones were evaluated. Four compounds showed neuroprotective activities with EC50 values of 3.5–11.9 μM.

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KW - Neuroprotective activity

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Neuroprotective constituents from the fruits of Maclura tricuspidata

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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