Neuroprotective effects of bovine colostrum on intracerebral hemorrhage-induced apoptotic neuronal cell death in rats

Sung Eun Kim, Il Gyu Ko, Mal Soon Shin, Chang Ju Kim, Young Gwan Ko, Han Jin Cho

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Brain cell death after intracerebral hemorrhage may be mediated in part by an apoptotic mechanism. Colostrum is the first milk produced by mammals for their young. It plays an important role in protection and development by providing various antibodies, growth factors and nutrients, and has been used for various diseases in many countries. In the present study, we investigated the anti- apoptotic effects of bovine colostrum using organotypic hippocampal slice cultures and an intracerebral hemorrhage animal model. We performed densitometric measurements of propidium iodide uptake, a step-down avoidance task, Nissl staining, and caspase-3 immunohistochemistry. The present results revealed that colostrum treatment significantly suppressed N-methyl-D-aspartic acid-induced neuronal cell death in the rat hippocampus. Moreover, colostrum treatment improved short-term memory by suppressing hemorrhage-induced apoptotic neuronal cell death and decreasing the volume of the lesion induced by intracerebral hemorrhage in the rat hippocampus. These results suggest that colostrum may have a beneficial role in recovering brain function following hemorrhagic stroke by suppressing apoptotic cell death.

Original languageEnglish
Pages (from-to)1715-1721
Number of pages7
JournalNeural Regeneration Research
Issue number22
Publication statusPublished - 2012 Aug 8
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2012, Editorial Board of Neural Regeneration Research. All rights reserved.


  • Apoptotic cell death
  • Bovine colostrums
  • Caspase-3
  • Hippocampus
  • Intracerebral hemorrhage
  • Memory
  • N-methyl-D-aspartic acid
  • Organotypic hippocampal slice culture

ASJC Scopus subject areas

  • Developmental Neuroscience


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