Neuroprotective effects of (-)-linalool against oxygen-glucose deprivation-induced neuronal injury

Hyeon Park, Geun Hee Seol, Sangwoo Ryu, In Young Choi

    Research output: Contribution to journalArticlepeer-review

    56 Citations (Scopus)

    Abstract

    (-)-Linalool, a major component of many essential oils, is widely used in cosmetics and flavoring ingredients as well as in traditional medicines. Although various in vitro and in vivo studies have shown that (-)-linalool has anti-convulsant, anti-nociceptive, anti-inflammatory and anti-oxidative properties, its anti-ischemic/hypoxic effects have yet to be determined. This study assessed the neuroprotective effects of (-)-linalool against oxygen-glucose deprivation/reoxygenation (OGD/R)-induced cortical neuronal injury, an in vitro model of ischemic stroke. (-)-Linalool significantly attenuated OGD/R-evoked cortical neuronal injury/death, although it did not inhibit N-methyl-d-aspartate (NMDA)-induced excitotoxicity. (-)-Linalool significantly reduced intracellular oxidative stress during OGD/R-induced injury, as well as scavenging peroxyl radicals (Trolox equivalents or TE = 3.8). This anti-oxidant effect was found to correlate with the restoration of OGD/R-induced decreases in the activities of SOD and catalase. In addition, (-)-linalool inhibited microglial migration induced by monocyte-chemoattractant protein-1 (MCP-1), a chemokine released by OGD/R. These findings show that (-)-linalool has neuroprotective effects against OGD/R-induced neuronal injury, which may be due to its anti-oxidant and anti-inflammatory activities. Detailed examination of the anti-ischemic mechanisms of (-)-linalool may indicate strategies for the development of drugs to treat cerebral ischemic injury.

    Original languageEnglish
    Pages (from-to)555-564
    Number of pages10
    JournalArchives of pharmacal research
    Volume39
    Issue number4
    DOIs
    Publication statusPublished - 2016 Apr 1

    Bibliographical note

    Funding Information:
    This research was supported by grants from the National Research Foundation of Korea (NRF) funded by the Korean government (MEST) (No. 2012R1A2A2A02007145) and a Korea University Grant (2015).

    Publisher Copyright:
    © 2016 The Pharmaceutical Society of Korea.

    Keywords

    • (-)-Linalool
    • Inflammation
    • Neuroprotection
    • Oxidative stress
    • Oxygen-glucose deprivation/reoxygenation

    ASJC Scopus subject areas

    • Molecular Medicine
    • Drug Discovery
    • Organic Chemistry

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