Abstract
Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzhemier's disease. Neuropathologically, PD is characterized by the selective loss of dopaminergic neurons. The neuronal toxicity of cytosolic excess dopamine (DA) has been described in many studies using several cell lines. In dopaminergic neurons, cytosolic excess DA is easily oxidized via monoamine oxidase (MAO)-B, tyrosinase or by auto-oxidation to produce neurotoxic metabolites such as DA quinone. So, in the present study, we induced cell death by treatment of DA (600 μM) in human neuroblastoma SH-SY5Y cell which was treated samples before 24 hr, and cell viability was measured by fluorescence activated cell sorter (FACs) analysis. Of those tested, the extracts of Poria cocos ()(whole), Gastrodia elata (rhizomes), Eucommia ulmoides ()(barks), Syneilesis palmata (whole), Acorus gramineus (rhizomes), Ligustrum japonicum (leaves) showed neuroprotective effects in dose dependent manner.
| Original language | English |
|---|---|
| Pages (from-to) | 41-45 |
| Number of pages | 5 |
| Journal | Korean Journal of Pharmacognosy |
| Volume | 40 |
| Issue number | 1 |
| Publication status | Published - 2009 Mar |
Keywords
- Dopamine
- EC
- FACS analysis
- Neuroprotective effects
ASJC Scopus subject areas
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
