Neuroprotective xanthones from the root bark of Cudrania tricuspidata

Jaeyoung Kwon; Nguyen Tuan Hiep; Dong Woo Kim; Bang Yeon Hwang; Hak Ju Lee; Woongchon Mar; Dongho Lee

doi:10.1021/np500364x

Neuroprotective xanthones from the root bark of Cudrania tricuspidata

Jaeyoung Kwon, Nguyen Tuan Hiep, Dong Woo Kim, Bang Yeon Hwang, Hak Ju Lee, Woongchon Mar, Dongho Lee

Department of Biosystems and Biotechnology

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

Seventeen new prenylated xanthones (1-17) were isolated from an ethyl acetate-soluble extract of root bark of Cudrania tricuspidata together with 17 previously identified xanthones. The structures of the new compounds were elucidated by spectroscopic methods. Six new compounds (3, 7, 8, 9, 15, and 16) and six known compounds (18-23) showed neuroprotective effects against 6-hydroxydopamine-induced cell death in human neuroblastoma SH-SY5Y cells, with EC₅₀ values of 0.7-16.6 μM.

Original language	English
Pages (from-to)	1893-1901
Number of pages	9
Journal	Journal of Natural Products
Volume	77
Issue number	8
DOIs	https://doi.org/10.1021/np500364x
Publication status	Published - 2014 Aug 22

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np500364x

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abstract = "Seventeen new prenylated xanthones (1-17) were isolated from an ethyl acetate-soluble extract of root bark of Cudrania tricuspidata together with 17 previously identified xanthones. The structures of the new compounds were elucidated by spectroscopic methods. Six new compounds (3, 7, 8, 9, 15, and 16) and six known compounds (18-23) showed neuroprotective effects against 6-hydroxydopamine-induced cell death in human neuroblastoma SH-SY5Y cells, with EC50 values of 0.7-16.6 μM.",

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AU - Kwon, Jaeyoung

AU - Hiep, Nguyen Tuan

AU - Kim, Dong Woo

AU - Hwang, Bang Yeon

AU - Lee, Hak Ju

AU - Mar, Woongchon

AU - Lee, Dongho

PY - 2014/8/22

Y1 - 2014/8/22

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AB - Seventeen new prenylated xanthones (1-17) were isolated from an ethyl acetate-soluble extract of root bark of Cudrania tricuspidata together with 17 previously identified xanthones. The structures of the new compounds were elucidated by spectroscopic methods. Six new compounds (3, 7, 8, 9, 15, and 16) and six known compounds (18-23) showed neuroprotective effects against 6-hydroxydopamine-induced cell death in human neuroblastoma SH-SY5Y cells, with EC50 values of 0.7-16.6 μM.

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ER -

Neuroprotective xanthones from the root bark of Cudrania tricuspidata

Abstract

ASJC Scopus subject areas

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