Neuroprotective xanthones from the root bark of Cudrania tricuspidata

Jaeyoung Kwon, Nguyen Tuan Hiep, Dong Woo Kim, Bang Yeon Hwang, Hak Ju Lee, Woongchon Mar, Dongho Lee

    Research output: Contribution to journalArticlepeer-review

    43 Citations (Scopus)

    Abstract

    Seventeen new prenylated xanthones (1-17) were isolated from an ethyl acetate-soluble extract of root bark of Cudrania tricuspidata together with 17 previously identified xanthones. The structures of the new compounds were elucidated by spectroscopic methods. Six new compounds (3, 7, 8, 9, 15, and 16) and six known compounds (18-23) showed neuroprotective effects against 6-hydroxydopamine-induced cell death in human neuroblastoma SH-SY5Y cells, with EC50 values of 0.7-16.6 μM.

    Original languageEnglish
    Pages (from-to)1893-1901
    Number of pages9
    JournalJournal of Natural Products
    Volume77
    Issue number8
    DOIs
    Publication statusPublished - 2014 Aug 22

    ASJC Scopus subject areas

    • Analytical Chemistry
    • Molecular Medicine
    • Pharmacology
    • Pharmaceutical Science
    • Drug Discovery
    • Complementary and alternative medicine
    • Organic Chemistry

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