Neurosteroid biosynthesis: Enzymatic pathways and neuroendocrine regulation by neurotransmitters and neuropeptides

Jean Luc Do Rego; Jae Young Seong; Delphine Burel; Jerôme Leprince; Van Luu-The; Kazuyoshi Tsutsui; Marie Christine Tonon; Georges Pelletier; Hubert Vaudry

doi:10.1016/j.yfrne.2009.05.006

Neurosteroid biosynthesis: Enzymatic pathways and neuroendocrine regulation by neurotransmitters and neuropeptides

Jean Luc Do Rego, Jae Young Seong, Delphine Burel, Jerôme Leprince, Van Luu-The, Kazuyoshi Tsutsui, Marie Christine Tonon, Georges Pelletier, Hubert Vaudry

Department of Biomedical Sciences

Research output: Contribution to journal › Review article › peer-review

301 Citations (Scopus)

Abstract

Neuroactive steroids synthesized in neuronal tissue, referred to as neurosteroids, are implicated in proliferation, differentiation, activity and survival of nerve cells. Neurosteroids are also involved in the control of a number of behavioral, neuroendocrine and metabolic processes such as regulation of food intake, locomotor activity, sexual activity, aggressiveness, anxiety, depression, body temperature and blood pressure. In this article, we summarize the current knowledge regarding the existence, neuroanatomical distribution and biological activity of the enzymes responsible for the biosynthesis of neurosteroids in the brain of vertebrates, and we review the neuronal mechanisms that control the activity of these enzymes. The observation that the activity of key steroidogenic enzymes is finely tuned by various neurotransmitters and neuropeptides strongly suggests that some of the central effects of these neuromodulators may be mediated via the regulation of neurosteroid production.

Original language	English
Pages (from-to)	259-301
Number of pages	43
Journal	Frontiers in Neuroendocrinology
Volume	30
Issue number	3
DOIs	https://doi.org/10.1016/j.yfrne.2009.05.006
Publication status	Published - 2009 Aug

Bibliographical note

Funding Information:
This work was supported by grants from the Institut National de la Santé et de la Recherche Médical (Inserm U413), The Ministère des Affaires Etrangères (France-Québec exchange Program No. PV-P-73-9 to G.P. and H.V.), a France-Québec exchange program (Inserm-Fonds de la Recherche en Santé du Québec, FRSQ to G.P. and H.V.), France–Korean exchange programs (Inserm-Korea Science and Engineering Foundation, KOSEF to J.Y.S. and H.V.; and Science and Technology Amical Research, STAR to J.L.D.R., J.Y.S. and H.V.), a France–Japan exchange program (Inserm-Japan Society for the Promotion of Science, JSPS to K.T., H.V. and J.L.D.R.), the Plate-forme Régionale de Recherche en Imagerie Cellulaire de Haute-Normandie (PRIMACEN), and the Conseil Régional de Haute-Normandie. H.V. is associated researcher at the Research Center in Molecular Endocrinology, Oncology and Genetics, Laval University, Quebec.

Keywords

Biological activities
Central nervous system
Neuroanatomical distribution
Neuropeptides
Neurosteroids
Neurotransmitters
Regulation
Steroidogenic enzymes

ASJC Scopus subject areas

Endocrine and Autonomic Systems

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10.1016/j.yfrne.2009.05.006

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title = "Neurosteroid biosynthesis: Enzymatic pathways and neuroendocrine regulation by neurotransmitters and neuropeptides",

abstract = "Neuroactive steroids synthesized in neuronal tissue, referred to as neurosteroids, are implicated in proliferation, differentiation, activity and survival of nerve cells. Neurosteroids are also involved in the control of a number of behavioral, neuroendocrine and metabolic processes such as regulation of food intake, locomotor activity, sexual activity, aggressiveness, anxiety, depression, body temperature and blood pressure. In this article, we summarize the current knowledge regarding the existence, neuroanatomical distribution and biological activity of the enzymes responsible for the biosynthesis of neurosteroids in the brain of vertebrates, and we review the neuronal mechanisms that control the activity of these enzymes. The observation that the activity of key steroidogenic enzymes is finely tuned by various neurotransmitters and neuropeptides strongly suggests that some of the central effects of these neuromodulators may be mediated via the regulation of neurosteroid production.",

keywords = "Biological activities, Central nervous system, Neuroanatomical distribution, Neuropeptides, Neurosteroids, Neurotransmitters, Regulation, Steroidogenic enzymes",

author = "{Do Rego}, {Jean Luc} and Seong, {Jae Young} and Delphine Burel and Jer{\^o}me Leprince and Van Luu-The and Kazuyoshi Tsutsui and Tonon, {Marie Christine} and Georges Pelletier and Hubert Vaudry",

note = "Funding Information: This work was supported by grants from the Institut National de la Sant{\'e} et de la Recherche M{\'e}dical (Inserm U413), The Minist{\`e}re des Affaires Etrang{\`e}res (France-Qu{\'e}bec exchange Program No. PV-P-73-9 to G.P. and H.V.), a France-Qu{\'e}bec exchange program (Inserm-Fonds de la Recherche en Sant{\'e} du Qu{\'e}bec, FRSQ to G.P. and H.V.), France–Korean exchange programs (Inserm-Korea Science and Engineering Foundation, KOSEF to J.Y.S. and H.V.; and Science and Technology Amical Research, STAR to J.L.D.R., J.Y.S. and H.V.), a France–Japan exchange program (Inserm-Japan Society for the Promotion of Science, JSPS to K.T., H.V. and J.L.D.R.), the Plate-forme R{\'e}gionale de Recherche en Imagerie Cellulaire de Haute-Normandie (PRIMACEN), and the Conseil R{\'e}gional de Haute-Normandie. H.V. is associated researcher at the Research Center in Molecular Endocrinology, Oncology and Genetics, Laval University, Quebec.",

year = "2009",

month = aug,

doi = "10.1016/j.yfrne.2009.05.006",

language = "English",

volume = "30",

pages = "259--301",

journal = "Frontiers in Neuroendocrinology",

issn = "0091-3022",

publisher = "Academic Press Inc.",

number = "3",

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T1 - Neurosteroid biosynthesis

T2 - Enzymatic pathways and neuroendocrine regulation by neurotransmitters and neuropeptides

AU - Do Rego, Jean Luc

AU - Seong, Jae Young

AU - Burel, Delphine

AU - Leprince, Jerôme

AU - Luu-The, Van

AU - Tsutsui, Kazuyoshi

AU - Tonon, Marie Christine

AU - Pelletier, Georges

AU - Vaudry, Hubert

N1 - Funding Information: This work was supported by grants from the Institut National de la Santé et de la Recherche Médical (Inserm U413), The Ministère des Affaires Etrangères (France-Québec exchange Program No. PV-P-73-9 to G.P. and H.V.), a France-Québec exchange program (Inserm-Fonds de la Recherche en Santé du Québec, FRSQ to G.P. and H.V.), France–Korean exchange programs (Inserm-Korea Science and Engineering Foundation, KOSEF to J.Y.S. and H.V.; and Science and Technology Amical Research, STAR to J.L.D.R., J.Y.S. and H.V.), a France–Japan exchange program (Inserm-Japan Society for the Promotion of Science, JSPS to K.T., H.V. and J.L.D.R.), the Plate-forme Régionale de Recherche en Imagerie Cellulaire de Haute-Normandie (PRIMACEN), and the Conseil Régional de Haute-Normandie. H.V. is associated researcher at the Research Center in Molecular Endocrinology, Oncology and Genetics, Laval University, Quebec.

PY - 2009/8

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N2 - Neuroactive steroids synthesized in neuronal tissue, referred to as neurosteroids, are implicated in proliferation, differentiation, activity and survival of nerve cells. Neurosteroids are also involved in the control of a number of behavioral, neuroendocrine and metabolic processes such as regulation of food intake, locomotor activity, sexual activity, aggressiveness, anxiety, depression, body temperature and blood pressure. In this article, we summarize the current knowledge regarding the existence, neuroanatomical distribution and biological activity of the enzymes responsible for the biosynthesis of neurosteroids in the brain of vertebrates, and we review the neuronal mechanisms that control the activity of these enzymes. The observation that the activity of key steroidogenic enzymes is finely tuned by various neurotransmitters and neuropeptides strongly suggests that some of the central effects of these neuromodulators may be mediated via the regulation of neurosteroid production.

AB - Neuroactive steroids synthesized in neuronal tissue, referred to as neurosteroids, are implicated in proliferation, differentiation, activity and survival of nerve cells. Neurosteroids are also involved in the control of a number of behavioral, neuroendocrine and metabolic processes such as regulation of food intake, locomotor activity, sexual activity, aggressiveness, anxiety, depression, body temperature and blood pressure. In this article, we summarize the current knowledge regarding the existence, neuroanatomical distribution and biological activity of the enzymes responsible for the biosynthesis of neurosteroids in the brain of vertebrates, and we review the neuronal mechanisms that control the activity of these enzymes. The observation that the activity of key steroidogenic enzymes is finely tuned by various neurotransmitters and neuropeptides strongly suggests that some of the central effects of these neuromodulators may be mediated via the regulation of neurosteroid production.

KW - Biological activities

KW - Central nervous system

KW - Neuroanatomical distribution

KW - Neuropeptides

KW - Neurosteroids

KW - Neurotransmitters

KW - Regulation

KW - Steroidogenic enzymes

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U2 - 10.1016/j.yfrne.2009.05.006

DO - 10.1016/j.yfrne.2009.05.006

M3 - Review article

C2 - 19505496

AN - SCOPUS:67849097168

SN - 0091-3022

VL - 30

SP - 259

EP - 301

JO - Frontiers in Neuroendocrinology

JF - Frontiers in Neuroendocrinology

IS - 3

ER -

Neurosteroid biosynthesis: Enzymatic pathways and neuroendocrine regulation by neurotransmitters and neuropeptides

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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