Neutralizing antibody responses to sars-cov-2 in korean patients who have recovered from covid-19

Yoon Jung Kim, Joon Yong Bae, Sohyun Bae, Soyoon Hwang, Ki Tae Kwon, Hyun Ha Chang, Won Kee Lee, Chunguang Cui, Gee Eun Lee, Shin Woo Kim, Man Seong Park

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Purpose: Neutralizing antibodies (NAbs) have been considered effective in preventing and treating viral infections. However, until now, the duration and clinical implications of antibody-mediated nature immunity in Koreans have remained unknown. Therefore, we examined NAbs levels and clinical characteristics in recovered coronavirus disease 2019 (COVID-19) patients. Materials and Methods: Blood samples were collected from 143 adult patients who had been diagnosed with and had recovered from COVID-19 from February to March in 2020 at a tertiary-care university-affiliated hospital in Daegu, Korea. A plaque reduction neutralization test was conducted to analyze NAb titers. Individualized questionnaires were used to identify patient clinical information. Results: The median number of days from symptom onset to the blood collection date was 109.0 (104.0; 115.0). The NAb titers ranged from 10 to 2560. The median NAb titer value was 40. Of the 143 patients, 68 (47.6%) patients had NAb titers ≥80, and 31 (21.7%) patients had NAb titers ≥160. The higher the age or disease severity, the higher the NAb titer. In univariate logistic regression, statistically significant predictors of high NAb titers (≥80) were age, myalgia, nausea or vomiting, dyspnea, and disease severity (p<0.05). Multivariable logistic regression showed that age ≥50 years (p=0.013) and moderate or higher disease severity (p<0.001) were factors associated with high NAb titers (≥80). None of the patients had reinfection of COVID-19. Conclusion: All recovered patients were found to have NAbs regardless of the NAb titers maintained by natural immunity. Age and disease severity during COVID-19 infection were associated with high NAb titers.

Original languageEnglish
Pages (from-to)584-592
Number of pages9
JournalYonsei medical journal
Issue number7
Publication statusPublished - 2021

Bibliographical note

Publisher Copyright:
© Yonsei University College of Medicine 2021.


  • COVID-19
  • Immunity
  • Neutralization assay
  • Neutralizing antibodies
  • SARS-CoV-2

ASJC Scopus subject areas

  • General Medicine


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