Neutrophil activation in patients with ASA-induced urticaria

Sung Jin Choi, Young Min Ye, Gyu Young Hur, Seung Youp Shin, Jae Ho Han, Hae Sim Park

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


The pathogenic mechanism of acetyl salicylic acid (ASA)-induced urticaria (AIU) is not fully understood. We compared the levels of neutrophil activation and related cytokines in patients with ASA-intolerant acute urticaria (AIAU) and ASA-intolerant chronic urticaria (AICU). A total of 51 patients with AIAU, 88 patients with AICU, and 102 normal controls (NC) were enrolled in this study. The serum levels of myeloperoxidase (MPO), interleukin-8 (IL-8), and IL-18 were compared among the three groups. The serum levels of MPO were highest in the AIAU group, followed by the AICU and NC groups, and the serum levels of IL-18 were significantly higher in the AIAU and AICU groups than in NC group. Within the AIU groups, significant correlations were noted between the levels of MPO and IL-8, and IL-8 and IL-18. In conclusion, neutrophil activation, which was associated with the levels of IL-8 and IL-18 in the AIAU group, may be involved in the pathogenic mechanism of AIU. A role for IL-18 in the pathogenesis of AIU is also suggested.

Original languageEnglish
Pages (from-to)244-249
Number of pages6
JournalJournal of Clinical Immunology
Issue number3
Publication statusPublished - 2008 May
Externally publishedYes

Bibliographical note

Funding Information:
Acknowledgements This study was supported by a grant from the Korean Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (03-PJ10-PG13-GD01-0002 and A050571).


  • ASA-intolerant acute urticaria
  • IL-18
  • IL-8
  • Neutrophil activation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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