Neutrophil activation in patients with ASA-induced urticaria

Sung Jin Choi; Young Min Ye; Gyu Young Hur; Seung Youp Shin; Jae Ho Han; Hae Sim Park

doi:10.1007/s10875-007-9165-0

Neutrophil activation in patients with ASA-induced urticaria

Sung Jin Choi, Young Min Ye, Gyu Young Hur, Seung Youp Shin, Jae Ho Han, Hae Sim Park

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

The pathogenic mechanism of acetyl salicylic acid (ASA)-induced urticaria (AIU) is not fully understood. We compared the levels of neutrophil activation and related cytokines in patients with ASA-intolerant acute urticaria (AIAU) and ASA-intolerant chronic urticaria (AICU). A total of 51 patients with AIAU, 88 patients with AICU, and 102 normal controls (NC) were enrolled in this study. The serum levels of myeloperoxidase (MPO), interleukin-8 (IL-8), and IL-18 were compared among the three groups. The serum levels of MPO were highest in the AIAU group, followed by the AICU and NC groups, and the serum levels of IL-18 were significantly higher in the AIAU and AICU groups than in NC group. Within the AIU groups, significant correlations were noted between the levels of MPO and IL-8, and IL-8 and IL-18. In conclusion, neutrophil activation, which was associated with the levels of IL-8 and IL-18 in the AIAU group, may be involved in the pathogenic mechanism of AIU. A role for IL-18 in the pathogenesis of AIU is also suggested.

Original language	English
Pages (from-to)	244-249
Number of pages	6
Journal	Journal of Clinical Immunology
Volume	28
Issue number	3
DOIs	https://doi.org/10.1007/s10875-007-9165-0
Publication status	Published - 2008 May
Externally published	Yes

Bibliographical note

Funding Information:
Acknowledgements This study was supported by a grant from the Korean Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (03-PJ10-PG13-GD01-0002 and A050571).

Keywords

ASA-intolerant acute urticaria
IL-18
IL-8
Neutrophil activation

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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Cite this

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title = "Neutrophil activation in patients with ASA-induced urticaria",

abstract = "The pathogenic mechanism of acetyl salicylic acid (ASA)-induced urticaria (AIU) is not fully understood. We compared the levels of neutrophil activation and related cytokines in patients with ASA-intolerant acute urticaria (AIAU) and ASA-intolerant chronic urticaria (AICU). A total of 51 patients with AIAU, 88 patients with AICU, and 102 normal controls (NC) were enrolled in this study. The serum levels of myeloperoxidase (MPO), interleukin-8 (IL-8), and IL-18 were compared among the three groups. The serum levels of MPO were highest in the AIAU group, followed by the AICU and NC groups, and the serum levels of IL-18 were significantly higher in the AIAU and AICU groups than in NC group. Within the AIU groups, significant correlations were noted between the levels of MPO and IL-8, and IL-8 and IL-18. In conclusion, neutrophil activation, which was associated with the levels of IL-8 and IL-18 in the AIAU group, may be involved in the pathogenic mechanism of AIU. A role for IL-18 in the pathogenesis of AIU is also suggested.",

keywords = "ASA-intolerant acute urticaria, IL-18, IL-8, Neutrophil activation",

author = "Choi, {Sung Jin} and Ye, {Young Min} and Hur, {Gyu Young} and Shin, {Seung Youp} and Han, {Jae Ho} and Park, {Hae Sim}",

note = "Funding Information: Acknowledgements This study was supported by a grant from the Korean Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (03-PJ10-PG13-GD01-0002 and A050571).",

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doi = "10.1007/s10875-007-9165-0",

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AU - Choi, Sung Jin

AU - Ye, Young Min

AU - Hur, Gyu Young

AU - Shin, Seung Youp

AU - Han, Jae Ho

AU - Park, Hae Sim

N1 - Funding Information: Acknowledgements This study was supported by a grant from the Korean Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (03-PJ10-PG13-GD01-0002 and A050571).

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N2 - The pathogenic mechanism of acetyl salicylic acid (ASA)-induced urticaria (AIU) is not fully understood. We compared the levels of neutrophil activation and related cytokines in patients with ASA-intolerant acute urticaria (AIAU) and ASA-intolerant chronic urticaria (AICU). A total of 51 patients with AIAU, 88 patients with AICU, and 102 normal controls (NC) were enrolled in this study. The serum levels of myeloperoxidase (MPO), interleukin-8 (IL-8), and IL-18 were compared among the three groups. The serum levels of MPO were highest in the AIAU group, followed by the AICU and NC groups, and the serum levels of IL-18 were significantly higher in the AIAU and AICU groups than in NC group. Within the AIU groups, significant correlations were noted between the levels of MPO and IL-8, and IL-8 and IL-18. In conclusion, neutrophil activation, which was associated with the levels of IL-8 and IL-18 in the AIAU group, may be involved in the pathogenic mechanism of AIU. A role for IL-18 in the pathogenesis of AIU is also suggested.

AB - The pathogenic mechanism of acetyl salicylic acid (ASA)-induced urticaria (AIU) is not fully understood. We compared the levels of neutrophil activation and related cytokines in patients with ASA-intolerant acute urticaria (AIAU) and ASA-intolerant chronic urticaria (AICU). A total of 51 patients with AIAU, 88 patients with AICU, and 102 normal controls (NC) were enrolled in this study. The serum levels of myeloperoxidase (MPO), interleukin-8 (IL-8), and IL-18 were compared among the three groups. The serum levels of MPO were highest in the AIAU group, followed by the AICU and NC groups, and the serum levels of IL-18 were significantly higher in the AIAU and AICU groups than in NC group. Within the AIU groups, significant correlations were noted between the levels of MPO and IL-8, and IL-8 and IL-18. In conclusion, neutrophil activation, which was associated with the levels of IL-8 and IL-18 in the AIAU group, may be involved in the pathogenic mechanism of AIU. A role for IL-18 in the pathogenesis of AIU is also suggested.

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Neutrophil activation in patients with ASA-induced urticaria

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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