New fabrication methods of bioactive and biodegradable scaffolds for bone tissue engineering

Youngmee Jung; Su Hee Kim; Sang Heon Kim; Soo Hyun Kim

doi:10.1177/0021955X11405465

New fabrication methods of bioactive and biodegradable scaffolds for bone tissue engineering

Youngmee Jung, Su Hee Kim, Sang Heon Kim, Soo Hyun Kim

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Bioceramic and polymers have been used as matrices for bone tissue engineering, and successful bone regeneration depends on cellular interaction with these matrices. The aim of this study was to fabricate polymer/ceramics composites with a novel sintering method. Also, we prepared homogenous porous poly(lactide-co-glycolide (PLGA) scaffolds in the supercritical CO₂. These scaffolds had homogenous porous structure and high tensile and compressive mechanical properties compared to the scaffold prepared by conventional solvent casting method. This study revealed that generating bioactive and porous polymer scaffolds with novel sintering method or supercritical fluid technique could be useful for bone tissue engineering.

Original language	English
Pages (from-to)	261-270
Number of pages	10
Journal	Journal of Cellular Plastics
Volume	47
Issue number	3
DOIs	https://doi.org/10.1177/0021955X11405465
Publication status	Published - 2011 May
Externally published	Yes

Keywords

composite scaffold
novel sintering
poly(lactide-co-glycolide)
supercritical fluid

ASJC Scopus subject areas

Chemistry(all)
Polymers and Plastics
Materials Chemistry

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abstract = "Bioceramic and polymers have been used as matrices for bone tissue engineering, and successful bone regeneration depends on cellular interaction with these matrices. The aim of this study was to fabricate polymer/ceramics composites with a novel sintering method. Also, we prepared homogenous porous poly(lactide-co-glycolide (PLGA) scaffolds in the supercritical CO2. These scaffolds had homogenous porous structure and high tensile and compressive mechanical properties compared to the scaffold prepared by conventional solvent casting method. This study revealed that generating bioactive and porous polymer scaffolds with novel sintering method or supercritical fluid technique could be useful for bone tissue engineering.",

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AU - Jung, Youngmee

AU - Kim, Su Hee

AU - Kim, Sang Heon

AU - Kim, Soo Hyun

PY - 2011/5

Y1 - 2011/5

N2 - Bioceramic and polymers have been used as matrices for bone tissue engineering, and successful bone regeneration depends on cellular interaction with these matrices. The aim of this study was to fabricate polymer/ceramics composites with a novel sintering method. Also, we prepared homogenous porous poly(lactide-co-glycolide (PLGA) scaffolds in the supercritical CO2. These scaffolds had homogenous porous structure and high tensile and compressive mechanical properties compared to the scaffold prepared by conventional solvent casting method. This study revealed that generating bioactive and porous polymer scaffolds with novel sintering method or supercritical fluid technique could be useful for bone tissue engineering.

AB - Bioceramic and polymers have been used as matrices for bone tissue engineering, and successful bone regeneration depends on cellular interaction with these matrices. The aim of this study was to fabricate polymer/ceramics composites with a novel sintering method. Also, we prepared homogenous porous poly(lactide-co-glycolide (PLGA) scaffolds in the supercritical CO2. These scaffolds had homogenous porous structure and high tensile and compressive mechanical properties compared to the scaffold prepared by conventional solvent casting method. This study revealed that generating bioactive and porous polymer scaffolds with novel sintering method or supercritical fluid technique could be useful for bone tissue engineering.

KW - composite scaffold

KW - novel sintering

KW - poly(lactide-co-glycolide)

KW - supercritical fluid

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New fabrication methods of bioactive and biodegradable scaffolds for bone tissue engineering

Abstract

Keywords

ASJC Scopus subject areas

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