NIR-II Photo-Amplified Sonodynamic Therapy Using Sodium Molybdenum Bronze Nanoplatform against Subcutaneous Staphylococcus Aureus Infection

Xiaojun He, Ji Ting Hou, Xiaoshuai Sun, Paramesh Jangili, Jusung An, Yuna Qian, Jong Seung Kim, Jianliang Shen

Research output: Contribution to journalArticlepeer-review

65 Citations (Scopus)


Ultrasound (US)-mediated sonodynamic therapy (SDT) has the advantages of non-invasiveness and deep tissue penetration. Nanosystems are prominently used in sonosensitization; however, most nano-sonosensitizers have a low reactive oxygen species (ROS) yield, thus restraining the application of SDT. Sodium molybdenum bronze nanoparticles (SMB NPs) with rich oxygen vacancies are developed and interlayer gaps of molybdenum trioxide nanobelts are expanded. Owing to the increased oxygen vacancy density and wide interlayer gap-induced narrower band gap of SMB NPs, the electrons (e) and holes (h+) generated by US are separated more rapidly, and oxygen vacancies prevent electrons–holes recombination under US irradiation. SMB NPs exhibit a second near-infrared (NIR-II) photothermal effect to promote the generation of ROS by the sonosensitizer. The SMB NPs system is successfully realized to eliminate Staphylococcus aureus (S. aureus) and dissipate biofilm. Therefore, multimodal therapy using SMB NPs serves as an effective and promising regimen for deep-seated bacterial infections. The newly developed Mo-based sonosensitizer is presented for the first time to demonstrate excellent antimicrobial activity through hyperthermia-promoting SDT therapeutics. This work proposes a novel strategy in the field of NIR-II photo-amplified SDT with Mo-based materials for bacterial eradication and other important biomedical applications.

Original languageEnglish
JournalAdvanced Functional Materials
Publication statusPublished - 2022 Sept 19

Bibliographical note

Funding Information:
X.H., J.‐T.H., and X.S. contributed equally to this work. This work was financially supported by the National Natural Science Foundation of China (21977081), Zhejiang Provincial Natural Science of Foundation of China (LZ19H180001), University of Chinese Academy of Sciences (WIBEZD2017001‐03), Wenzhou Science and Technology Plan Project (ZG2021035), Wenzhou Medical University (KYYW201901). The authors also gratefully acknowledge the financial support received from the National Research Foundation of Korea (CRI project nos. 2018R1A3B1052702, 2019M3E5D1A01068998, J.S.K.).

Publisher Copyright:
© 2022 Wiley-VCH GmbH.


  • anti-infection
  • oxygen vacancies
  • photothermal
  • sodium molybdenum bronze
  • sonodynamic

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • General Chemistry
  • General Materials Science
  • Electrochemistry
  • Biomaterials


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