Abstract
Be quick or take your time, depending on your goal: A microflow method for the generation and transformation of o-, m-, and p-nitro-substituted aryl lithium compounds enabled the selective use of either the kinetically or the thermodynamically preferred intermediate. In the example pictured, a residence time of 0.06 s at -48 °C led to the formation of 1, whereas 2 was obtained exclusively when the residence time was extended to 63 s.
Original language | English |
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Pages (from-to) | 8063-8065 |
Number of pages | 3 |
Journal | Angewandte Chemie - International Edition |
Volume | 48 |
Issue number | 43 |
DOIs | |
Publication status | Published - 2009 Oct 12 |
Externally published | Yes |
Keywords
- Arenes
- Kinetic control
- Lithiation
- Microreactors
- Thermodynamic control
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)