Nmdmc overexpression extends Drosophila lifespan and reduces levels of mitochondrial reactive oxygen species

Suyeun Yu, Yeogil Jang, Donggi Paik, Eunil Lee, Joong Jean Park

    Research output: Contribution to journalArticlepeer-review

    18 Citations (Scopus)

    Abstract

    NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase (NMDMC) is a bifunctional enzyme involved in folate-dependent metabolism and highly expressed in rapidly proliferating cells. However, Nmdmc physiological roles remain unveiled. We found that ubiquitous Nmdmc overexpression enhanced Drosophila lifespan and stress resistance. Interestingly, Nmdmc overexpression in the fat body was sufficient to increase lifespan and tolerance against oxidative stress. In addition, these conditions coincided with significant decreases in the levels of mitochondrial ROS and Hsp22 as well as with a significant increase in the copy number of mitochondrial DNA. These results suggest that Nmdmc overexpression should be beneficial for mitochondrial homeostasis and increasing lifespan.

    Original languageEnglish
    Pages (from-to)845-850
    Number of pages6
    JournalBiochemical and biophysical research communications
    Volume465
    Issue number4
    DOIs
    Publication statusPublished - 2015 Oct 2

    Bibliographical note

    Publisher Copyright:
    © 2015 Elsevier Inc. All rights reserved.

    Keywords

    • Drosophila
    • Longevity
    • Mitochondrial DNA
    • NMDMC
    • Reactive oxygen species

    ASJC Scopus subject areas

    • Biophysics
    • Biochemistry
    • Molecular Biology
    • Cell Biology

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