No association between dopamine D4 receptor gene -521 C/T polymorphism and tardive dyskinesia in schizophrenia

Heon Jeong Lee; Seung Gul Kang; Jung Eun Choi; Jong Woo Paik; Yong Ku Kim; Seung Hyun Kim; Min Soo Lee; Sook Haeng Joe; In Kwa Jung; Leen Kim

doi:10.1159/000103576

No association between dopamine D4 receptor gene -521 C/T polymorphism and tardive dyskinesia in schizophrenia

Heon Jeong Lee, Seung Gul Kang, Jung Eun Choi, Jong Woo Paik, Yong Ku Kim, Seung Hyun Kim, Min Soo Lee, Sook Haeng Joe, In Kwa Jung, Leen Kim

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Tardive dyskinesia (TD) is a long-term adverse effect of antipsychotics. We evaluated whether a candidate functional polymorphism of the dopamine D4 receptor (DRD4) gene is associated with drug-induced TD in 209 Korean schizophrenic patients with TD (n = 83) and without TD (n = 126) who were matched for antipsychotic drug exposure and other relevant variables. There was no significant association of the genotype and allele frequencies determined by the -521 C/T SNP of DRD4 between TD and non-TD patients. In addition, there was no significant difference in terms of total Abnormal Involuntary Movement Scale scores among the 3 genotype groups. Within the limitations imposed by the size of the clinical sample, these findings suggest that the DRD4 -521 C/T SNP does not contribute significantly to the risk for TD.

Original language	English
Pages (from-to)	47-51
Number of pages	5
Journal	Neuropsychobiology
Volume	55
Issue number	1
DOIs	https://doi.org/10.1159/000103576
Publication status	Published - 2007 Jun

Keywords

Dopamine D4 receptor
Polymorphism
Schizophrenia
Tardive dyskinesia

ASJC Scopus subject areas

Neuropsychology and Physiological Psychology
Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000103576

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title = "No association between dopamine D4 receptor gene -521 C/T polymorphism and tardive dyskinesia in schizophrenia",

abstract = "Tardive dyskinesia (TD) is a long-term adverse effect of antipsychotics. We evaluated whether a candidate functional polymorphism of the dopamine D4 receptor (DRD4) gene is associated with drug-induced TD in 209 Korean schizophrenic patients with TD (n = 83) and without TD (n = 126) who were matched for antipsychotic drug exposure and other relevant variables. There was no significant association of the genotype and allele frequencies determined by the -521 C/T SNP of DRD4 between TD and non-TD patients. In addition, there was no significant difference in terms of total Abnormal Involuntary Movement Scale scores among the 3 genotype groups. Within the limitations imposed by the size of the clinical sample, these findings suggest that the DRD4 -521 C/T SNP does not contribute significantly to the risk for TD.",

keywords = "Dopamine D4 receptor, Polymorphism, Schizophrenia, Tardive dyskinesia",

author = "Lee, {Heon Jeong} and Kang, {Seung Gul} and Choi, {Jung Eun} and Paik, {Jong Woo} and Kim, {Yong Ku} and Kim, {Seung Hyun} and Lee, {Min Soo} and Joe, {Sook Haeng} and Jung, {In Kwa} and Leen Kim",

year = "2007",

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doi = "10.1159/000103576",

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AU - Lee, Heon Jeong

AU - Kang, Seung Gul

AU - Choi, Jung Eun

AU - Paik, Jong Woo

AU - Kim, Yong Ku

AU - Kim, Seung Hyun

AU - Lee, Min Soo

AU - Joe, Sook Haeng

AU - Jung, In Kwa

AU - Kim, Leen

PY - 2007/6

Y1 - 2007/6

N2 - Tardive dyskinesia (TD) is a long-term adverse effect of antipsychotics. We evaluated whether a candidate functional polymorphism of the dopamine D4 receptor (DRD4) gene is associated with drug-induced TD in 209 Korean schizophrenic patients with TD (n = 83) and without TD (n = 126) who were matched for antipsychotic drug exposure and other relevant variables. There was no significant association of the genotype and allele frequencies determined by the -521 C/T SNP of DRD4 between TD and non-TD patients. In addition, there was no significant difference in terms of total Abnormal Involuntary Movement Scale scores among the 3 genotype groups. Within the limitations imposed by the size of the clinical sample, these findings suggest that the DRD4 -521 C/T SNP does not contribute significantly to the risk for TD.

AB - Tardive dyskinesia (TD) is a long-term adverse effect of antipsychotics. We evaluated whether a candidate functional polymorphism of the dopamine D4 receptor (DRD4) gene is associated with drug-induced TD in 209 Korean schizophrenic patients with TD (n = 83) and without TD (n = 126) who were matched for antipsychotic drug exposure and other relevant variables. There was no significant association of the genotype and allele frequencies determined by the -521 C/T SNP of DRD4 between TD and non-TD patients. In addition, there was no significant difference in terms of total Abnormal Involuntary Movement Scale scores among the 3 genotype groups. Within the limitations imposed by the size of the clinical sample, these findings suggest that the DRD4 -521 C/T SNP does not contribute significantly to the risk for TD.

KW - Dopamine D4 receptor

KW - Polymorphism

KW - Schizophrenia

KW - Tardive dyskinesia

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U2 - 10.1159/000103576

DO - 10.1159/000103576

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SN - 0302-282X

VL - 55

SP - 47

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JO - Neuropsychobiology

JF - Neuropsychobiology

IS - 1

ER -

No association between dopamine D4 receptor gene -521 C/T polymorphism and tardive dyskinesia in schizophrenia

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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