No association between Serotonin 2A receptor -1438 A/G polymorphism and smoking behavior in young Korean male subjects

Heon Jeong Lee; Se Won Lim; Jong Woo Paik; Min Soo Lee; Leen Kim

No association between Serotonin 2A receptor -1438 A/G polymorphism and smoking behavior in young Korean male subjects

Heon Jeong Lee, Se Won Lim, Jong Woo Paik, Min Soo Lee, Leen Kim

Research output: Contribution to journal › Article › peer-review

Abstract

Smoking behavior has been regarded as being influenced by genetic factors. The aim of this study was to investigate if the -1438 A/G polymorphism of the Serotonin 2A receptor (5-HTR2A) gene is related to nicotine dependence, since this receptor modulates the mesolimbic dopamine system which is associated with drug addiction. The Fagerstrom test for nicotine dependence was used to determine the smoking behavior. A genotyping based PCR method was performed in 72 smokers and 134 nonsmokers. The -1438 A/G SNP showed no significant difference between the smokers and non-smokers in either the genotype or the allele frequency (p=0.84, p=0.85). These findings suggest that the -1438 A/G polymorphism of 5-HTR2A does not play a major role in the susceptibility to nicotine dependence in the Korean population.

Original language	English
Pages (from-to)	43-45
Number of pages	3
Journal	Clinical Psychopharmacology and Neuroscience
Volume	3
Issue number	1
Publication status	Published - 2005 Dec

Keywords

5-HTR2A
Polymorphism
Serotonin
Smoking

ASJC Scopus subject areas

Psychiatry and Mental health
Behavioral Neuroscience
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "No association between Serotonin 2A receptor -1438 A/G polymorphism and smoking behavior in young Korean male subjects",

abstract = "Smoking behavior has been regarded as being influenced by genetic factors. The aim of this study was to investigate if the -1438 A/G polymorphism of the Serotonin 2A receptor (5-HTR2A) gene is related to nicotine dependence, since this receptor modulates the mesolimbic dopamine system which is associated with drug addiction. The Fagerstrom test for nicotine dependence was used to determine the smoking behavior. A genotyping based PCR method was performed in 72 smokers and 134 nonsmokers. The -1438 A/G SNP showed no significant difference between the smokers and non-smokers in either the genotype or the allele frequency (p=0.84, p=0.85). These findings suggest that the -1438 A/G polymorphism of 5-HTR2A does not play a major role in the susceptibility to nicotine dependence in the Korean population.",

keywords = "5-HTR2A, Polymorphism, Serotonin, Smoking",

author = "Lee, {Heon Jeong} and Lim, {Se Won} and Paik, {Jong Woo} and Lee, {Min Soo} and Leen Kim",

year = "2005",

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language = "English",

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journal = "Clinical Psychopharmacology and Neuroscience",

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T1 - No association between Serotonin 2A receptor -1438 A/G polymorphism and smoking behavior in young Korean male subjects

AU - Lee, Heon Jeong

AU - Lim, Se Won

AU - Paik, Jong Woo

AU - Lee, Min Soo

AU - Kim, Leen

PY - 2005/12

Y1 - 2005/12

N2 - Smoking behavior has been regarded as being influenced by genetic factors. The aim of this study was to investigate if the -1438 A/G polymorphism of the Serotonin 2A receptor (5-HTR2A) gene is related to nicotine dependence, since this receptor modulates the mesolimbic dopamine system which is associated with drug addiction. The Fagerstrom test for nicotine dependence was used to determine the smoking behavior. A genotyping based PCR method was performed in 72 smokers and 134 nonsmokers. The -1438 A/G SNP showed no significant difference between the smokers and non-smokers in either the genotype or the allele frequency (p=0.84, p=0.85). These findings suggest that the -1438 A/G polymorphism of 5-HTR2A does not play a major role in the susceptibility to nicotine dependence in the Korean population.

AB - Smoking behavior has been regarded as being influenced by genetic factors. The aim of this study was to investigate if the -1438 A/G polymorphism of the Serotonin 2A receptor (5-HTR2A) gene is related to nicotine dependence, since this receptor modulates the mesolimbic dopamine system which is associated with drug addiction. The Fagerstrom test for nicotine dependence was used to determine the smoking behavior. A genotyping based PCR method was performed in 72 smokers and 134 nonsmokers. The -1438 A/G SNP showed no significant difference between the smokers and non-smokers in either the genotype or the allele frequency (p=0.84, p=0.85). These findings suggest that the -1438 A/G polymorphism of 5-HTR2A does not play a major role in the susceptibility to nicotine dependence in the Korean population.

KW - 5-HTR2A

KW - Polymorphism

KW - Serotonin

KW - Smoking

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M3 - Article

AN - SCOPUS:33645009356

SN - 1738-1088

VL - 3

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JO - Clinical Psychopharmacology and Neuroscience

JF - Clinical Psychopharmacology and Neuroscience

IS - 1

ER -

No association between Serotonin 2A receptor -1438 A/G polymorphism and smoking behavior in young Korean male subjects

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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