No association between the brain-derived neurotrophic factor gene Val66Met polymorphism and tardive dyskinesia in schizophrenic patients

Seung Gul Kang; Jung Eun Choi; Hyonggin An; Se Won Lim; Heon Jeong Lee; Changsu Han; Yong Ku Kim; Seung Hyun Kim; Sung Nam Cho; Min Soo Lee; Sook Haeng Joe; In Kwa Jung; Leen Kim

doi:10.1016/j.pnpbp.2008.05.016

No association between the brain-derived neurotrophic factor gene Val66Met polymorphism and tardive dyskinesia in schizophrenic patients

Seung Gul Kang, Jung Eun Choi, Hyonggin An, Se Won Lim, Heon Jeong Lee, Changsu Han, Yong Ku Kim, Seung Hyun Kim, Sung Nam Cho, Min Soo Lee, Sook Haeng Joe, In Kwa Jung, Leen Kim

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Objective: This study investigated whether the brain-derived neurotrophic factor (BDNF) gene Val66Met single-nucleotide polymorphism (SNP) is associated with antipsychotic-induced tardive dyskinesia (TD) in schizophrenia. Methods: Genotyping was performed for the BDNF gene Val66Met SNP in Korean schizophrenic patients with (n = 83) and without TD (n = 126) who were matched for antipsychotic drug exposure and other relevant variables. Results: The frequencies of genotypes (χ² = 2.37, p = 0.306) and alleles (χ² = 0.03, p = 0.867) did not differ significantly between these two groups. Conclusion: These findings suggest that the BDNF polymorphism does not play a major role in the susceptibility to TD in schizophrenic patients. Crown

Original language	English
Pages (from-to)	1545-1548
Number of pages	4
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Volume	32
Issue number	6
DOIs	https://doi.org/10.1016/j.pnpbp.2008.05.016
Publication status	Published - 2008 Aug 1

Bibliographical note

Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.

Keywords

Brain-derived neurotrophic factor
Polymorphism
Schizophrenia
Tardive dyskinesia

ASJC Scopus subject areas

Pharmacology
Biological Psychiatry

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10.1016/j.pnpbp.2008.05.016

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Kang, S. G., Choi, J. E., An, H., Lim, S. W., Lee, H. J., Han, C., Kim, Y. K., Kim, S. H., Cho, S. N., Lee, M. S., Joe, S. H., Jung, I. K., & Kim, L. (2008). No association between the brain-derived neurotrophic factor gene Val66Met polymorphism and tardive dyskinesia in schizophrenic patients. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 32(6), 1545-1548. https://doi.org/10.1016/j.pnpbp.2008.05.016

No association between the brain-derived neurotrophic factor gene Val66Met polymorphism and tardive dyskinesia in schizophrenic patients. / Kang, Seung Gul; Choi, Jung Eun; An, Hyonggin et al.
In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 32, No. 6, 01.08.2008, p. 1545-1548.

Research output: Contribution to journal › Article › peer-review

Kang, SG, Choi, JE, An, H, Lim, SW, Lee, HJ, Han, C, Kim, YK, Kim, SH, Cho, SN, Lee, MS, Joe, SH, Jung, IK & Kim, L 2008, 'No association between the brain-derived neurotrophic factor gene Val66Met polymorphism and tardive dyskinesia in schizophrenic patients', Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 32, no. 6, pp. 1545-1548. https://doi.org/10.1016/j.pnpbp.2008.05.016

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abstract = "Objective: This study investigated whether the brain-derived neurotrophic factor (BDNF) gene Val66Met single-nucleotide polymorphism (SNP) is associated with antipsychotic-induced tardive dyskinesia (TD) in schizophrenia. Methods: Genotyping was performed for the BDNF gene Val66Met SNP in Korean schizophrenic patients with (n = 83) and without TD (n = 126) who were matched for antipsychotic drug exposure and other relevant variables. Results: The frequencies of genotypes (χ2 = 2.37, p = 0.306) and alleles (χ2 = 0.03, p = 0.867) did not differ significantly between these two groups. Conclusion: These findings suggest that the BDNF polymorphism does not play a major role in the susceptibility to TD in schizophrenic patients. Crown",

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AU - Lim, Se Won

AU - Lee, Heon Jeong

AU - Han, Changsu

AU - Kim, Yong Ku

AU - Kim, Seung Hyun

AU - Cho, Sung Nam

AU - Lee, Min Soo

AU - Joe, Sook Haeng

AU - Jung, In Kwa

AU - Kim, Leen

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AB - Objective: This study investigated whether the brain-derived neurotrophic factor (BDNF) gene Val66Met single-nucleotide polymorphism (SNP) is associated with antipsychotic-induced tardive dyskinesia (TD) in schizophrenia. Methods: Genotyping was performed for the BDNF gene Val66Met SNP in Korean schizophrenic patients with (n = 83) and without TD (n = 126) who were matched for antipsychotic drug exposure and other relevant variables. Results: The frequencies of genotypes (χ2 = 2.37, p = 0.306) and alleles (χ2 = 0.03, p = 0.867) did not differ significantly between these two groups. Conclusion: These findings suggest that the BDNF polymorphism does not play a major role in the susceptibility to TD in schizophrenic patients. Crown

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No association between the brain-derived neurotrophic factor gene Val66Met polymorphism and tardive dyskinesia in schizophrenic patients

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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