No borna disease virus-specific RNA detected in blood of race horses and jockeys

Yong Ku Kim; Kyung Bo Noh; Chang Su Han; Ju Young Moon; Do Kyung Yoon; Ki Joon Song; Dai Jin Kim; Marta Kubera; Michael Maes; Jin Won Song

doi:10.1111/j.1601-5215.2006.00118.x

No borna disease virus-specific RNA detected in blood of race horses and jockeys

Yong Ku Kim, Kyung Bo Noh, Chang Su Han, Ju Young Moon, Do Kyung Yoon, Ki Joon Song, Dai Jin Kim, Marta Kubera, Michael Maes, Jin Won Song

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Background: Borna disease virus (BDV) predominantly infects horses and sheep, causing a broad range of behavioural disorders. It is controversial whether BDV infects humans and causes psychiatric disorders. Objectives: We searched for BDV-derived nucleic acids in blood of race horses and jockeys riding the horses. Methods: We assayed for the BDV genome in RNA extracted from peripheral blood mononuclear cells (PBMC) of 39 race horses and 48 jockeys. Two polymerase chain reaction protocols [one-tube reverse transcription-polymerase chain reaction (RT-PCR) and two-step RT-PCR] were used to assay BDV p24 and p40 transcripts. Results: The p24 and p40 viral nucleic acid sequences were not detected in the PBMC RNAs from any of the race horses or jockeys. Conclusions: These data do not support an epidemiological association between BDV infection, race horses and humans.

Original language	English
Pages (from-to)	177-180
Number of pages	4
Journal	Acta Neuropsychiatrica
Volume	18
Issue number	3-4
DOIs	https://doi.org/10.1111/j.1601-5215.2006.00118.x
Publication status	Published - 2006

Keywords

BDV
Horse
Jockey
PCR
Psychiatric disorder

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1601-5215.2006.00118.x

Cite this

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title = "No borna disease virus-specific RNA detected in blood of race horses and jockeys",

abstract = "Background: Borna disease virus (BDV) predominantly infects horses and sheep, causing a broad range of behavioural disorders. It is controversial whether BDV infects humans and causes psychiatric disorders. Objectives: We searched for BDV-derived nucleic acids in blood of race horses and jockeys riding the horses. Methods: We assayed for the BDV genome in RNA extracted from peripheral blood mononuclear cells (PBMC) of 39 race horses and 48 jockeys. Two polymerase chain reaction protocols [one-tube reverse transcription-polymerase chain reaction (RT-PCR) and two-step RT-PCR] were used to assay BDV p24 and p40 transcripts. Results: The p24 and p40 viral nucleic acid sequences were not detected in the PBMC RNAs from any of the race horses or jockeys. Conclusions: These data do not support an epidemiological association between BDV infection, race horses and humans.",

keywords = "BDV, Horse, Jockey, PCR, Psychiatric disorder",

author = "Kim, {Yong Ku} and Noh, {Kyung Bo} and Han, {Chang Su} and Moon, {Ju Young} and Yoon, {Do Kyung} and Song, {Ki Joon} and Kim, {Dai Jin} and Marta Kubera and Michael Maes and Song, {Jin Won}",

year = "2006",

doi = "10.1111/j.1601-5215.2006.00118.x",

language = "English",

volume = "18",

pages = "177--180",

journal = "Acta Neuropsychiatrica",

issn = "0924-2708",

publisher = "Wiley-Blackwell",

number = "3-4",

}

TY - JOUR

T1 - No borna disease virus-specific RNA detected in blood of race horses and jockeys

AU - Kim, Yong Ku

AU - Noh, Kyung Bo

AU - Han, Chang Su

AU - Moon, Ju Young

AU - Yoon, Do Kyung

AU - Song, Ki Joon

AU - Kim, Dai Jin

AU - Kubera, Marta

AU - Maes, Michael

AU - Song, Jin Won

PY - 2006

Y1 - 2006

N2 - Background: Borna disease virus (BDV) predominantly infects horses and sheep, causing a broad range of behavioural disorders. It is controversial whether BDV infects humans and causes psychiatric disorders. Objectives: We searched for BDV-derived nucleic acids in blood of race horses and jockeys riding the horses. Methods: We assayed for the BDV genome in RNA extracted from peripheral blood mononuclear cells (PBMC) of 39 race horses and 48 jockeys. Two polymerase chain reaction protocols [one-tube reverse transcription-polymerase chain reaction (RT-PCR) and two-step RT-PCR] were used to assay BDV p24 and p40 transcripts. Results: The p24 and p40 viral nucleic acid sequences were not detected in the PBMC RNAs from any of the race horses or jockeys. Conclusions: These data do not support an epidemiological association between BDV infection, race horses and humans.

AB - Background: Borna disease virus (BDV) predominantly infects horses and sheep, causing a broad range of behavioural disorders. It is controversial whether BDV infects humans and causes psychiatric disorders. Objectives: We searched for BDV-derived nucleic acids in blood of race horses and jockeys riding the horses. Methods: We assayed for the BDV genome in RNA extracted from peripheral blood mononuclear cells (PBMC) of 39 race horses and 48 jockeys. Two polymerase chain reaction protocols [one-tube reverse transcription-polymerase chain reaction (RT-PCR) and two-step RT-PCR] were used to assay BDV p24 and p40 transcripts. Results: The p24 and p40 viral nucleic acid sequences were not detected in the PBMC RNAs from any of the race horses or jockeys. Conclusions: These data do not support an epidemiological association between BDV infection, race horses and humans.

KW - BDV

KW - Horse

KW - Jockey

KW - PCR

KW - Psychiatric disorder

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U2 - 10.1111/j.1601-5215.2006.00118.x

DO - 10.1111/j.1601-5215.2006.00118.x

M3 - Article

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SN - 0924-2708

VL - 18

SP - 177

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JO - Acta Neuropsychiatrica

JF - Acta Neuropsychiatrica

IS - 3-4

ER -

No borna disease virus-specific RNA detected in blood of race horses and jockeys

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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