No evidence for an association between dopamine D2 receptor polymorphisms and tardive dyskinesia in Korean schizophrenia patients

Young Min Park, Seung Gul Kang, Jung Eun Choi, Yong Ku Kim, Seung Hyun Kim, Ji Young Park, Leen Kim, Heon Jeong Lee

    Research output: Contribution to journalArticlepeer-review

    13 Citations (Scopus)

    Abstract

    Objective Tardive dyskinesia (TD) is a long-term adverse effect of antipsychotic. Dopaminergic activity in the nigrostriatal system have been proposed to be involved in development of TD and dopamine D2 receptors (DRD2) has been regarded as a candidate gene for TD because the antipsychotics have potent antagonism DRD2. This study was aimed to find the relationship between DRD2 gene and antipsychotic- induced TD. Methods We evaluated whether 5 DRD2 single nucleotide polymorphisms (- 41Cins>del/TaqID/NcoI/Ser311Cys/TaqIA) are associated with antipsychotic-induced TD in 263 Korean schizophrenia patients with (n=100) and without TD (n=163) who were matched for antipsychotic drug exposure and other relevant variables. Haplotype analyses were also performed. Results None of 5 polymorphisms were found to be significantly associated with TD and with TD severity as measured by Abnormal Involuntary Movement Scale. Overall haplotype (-141Cins>del/TaqID/NcoI/Ser311Cys/TaqIA) frequency was also not significantly different between TD and non-TD groups, although one rare haplotype (I-D1-T-G-A1) showed significantly different frequency between TD and non-TD groups (2.7% vs. 8.5%, respectively, p=0.031). Conclusion The present study does not support that DRD2 gene may be involved in TD in the Korean population, although further studies are warranted.

    Original languageEnglish
    Pages (from-to)49-54
    Number of pages6
    JournalPsychiatry Investigation
    Volume8
    Issue number1
    DOIs
    Publication statusPublished - 2011 Mar

    Keywords

    • Association
    • Dopamine receptor
    • Polymorphism
    • Schizophrenia
    • Tardive dyskinesia

    ASJC Scopus subject areas

    • Psychiatry and Mental health
    • Biological Psychiatry

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