NO inhibitory diterpenoids as potential anti-inflammatory agents from Euphorbia antiquorum

Lijun An, Yue Liang, Xueyuan Yang, Huimei Wang, Jie Zhang, Muhetaer Tuerhong, Dihua Li, Chunyan Wang, Dongho Lee, Jing Xu, Ling Shuai, Jin Jin, Yuanqiang Guo

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


Two new ent-atisane-type diterpenoids (1 and 2), three new lathyrane-type diterpenoids (3–5), and seven known analogues (6–12) were isolated from Euphorbia antiquorum. The structures of these diterpenoids were established by analysis of their NMR, MS, and electronic circular dichroism data. The anti-inflammatory activities were evaluated biologically and compounds 1, 4, 7, 8, and 10 displayed strong NO inhibitory effects with IC50 values less than 40 μM. The potential anti-inflammatory mechanism was also investigated using molecular docking and Western blotting.

Original languageEnglish
Article number103237
JournalBioorganic Chemistry
Publication statusPublished - 2019 Nov

Bibliographical note

Funding Information:
This research was financially supported by the National Natural Science Foundation of China (Nos. U1703107 , U1801288 , and 21665013 ), the National Key Research and Development Program of China (No. 2018YFA0507204 ), Hundred Young Academic Leaders Program of Nankai University, State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University, No. CMEMR2018-B02 ), the Fundamental Research Funds for the Central Universities, Nankai University (Nos. 63191142 and 63191731 ), and the Natural Science Foundation of Tianjin (No. 16JCQNJC13500 ).

Publisher Copyright:
© 2019 Elsevier Inc.


  • Diterpenoids
  • Euphorbia antiquorum
  • Inflammation
  • Molecular docking
  • NO inhibitory effects

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Drug Discovery
  • Organic Chemistry


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