NO inhibitory diterpenoids as potential anti-inflammatory agents from Euphorbia antiquorum

Lijun An; Yue Liang; Xueyuan Yang; Huimei Wang; Jie Zhang; Muhetaer Tuerhong; Dihua Li; Chunyan Wang; Dongho Lee; Jing Xu; Ling Shuai; Jin Jin; Yuanqiang Guo

doi:10.1016/j.bioorg.2019.103237

NO inhibitory diterpenoids as potential anti-inflammatory agents from Euphorbia antiquorum

Lijun An, Yue Liang, Xueyuan Yang, Huimei Wang, Jie Zhang, Muhetaer Tuerhong, Dihua Li, Chunyan Wang, Dongho Lee, Jing Xu, Ling Shuai, Jin Jin, Yuanqiang Guo

Department of Biosystems and Biotechnology

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Two new ent-atisane-type diterpenoids (1 and 2), three new lathyrane-type diterpenoids (3–5), and seven known analogues (6–12) were isolated from Euphorbia antiquorum. The structures of these diterpenoids were established by analysis of their NMR, MS, and electronic circular dichroism data. The anti-inflammatory activities were evaluated biologically and compounds 1, 4, 7, 8, and 10 displayed strong NO inhibitory effects with IC₅₀ values less than 40 μM. The potential anti-inflammatory mechanism was also investigated using molecular docking and Western blotting.

Original language	English
Article number	103237
Journal	Bioorganic Chemistry
Volume	92
DOIs	https://doi.org/10.1016/j.bioorg.2019.103237
Publication status	Published - 2019 Nov

Bibliographical note

Funding Information:
This research was financially supported by the National Natural Science Foundation of China (Nos. U1703107 , U1801288 , and 21665013 ), the National Key Research and Development Program of China (No. 2018YFA0507204 ), Hundred Young Academic Leaders Program of Nankai University, State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University, No. CMEMR2018-B02 ), the Fundamental Research Funds for the Central Universities, Nankai University (Nos. 63191142 and 63191731 ), and the Natural Science Foundation of Tianjin (No. 16JCQNJC13500 ).

Publisher Copyright:
© 2019 Elsevier Inc.

Keywords

Diterpenoids
Euphorbia antiquorum
Inflammation
Molecular docking
NO inhibitory effects

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Drug Discovery
Organic Chemistry

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10.1016/j.bioorg.2019.103237

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abstract = "Two new ent-atisane-type diterpenoids (1 and 2), three new lathyrane-type diterpenoids (3–5), and seven known analogues (6–12) were isolated from Euphorbia antiquorum. The structures of these diterpenoids were established by analysis of their NMR, MS, and electronic circular dichroism data. The anti-inflammatory activities were evaluated biologically and compounds 1, 4, 7, 8, and 10 displayed strong NO inhibitory effects with IC50 values less than 40 μM. The potential anti-inflammatory mechanism was also investigated using molecular docking and Western blotting.",

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author = "Lijun An and Yue Liang and Xueyuan Yang and Huimei Wang and Jie Zhang and Muhetaer Tuerhong and Dihua Li and Chunyan Wang and Dongho Lee and Jing Xu and Ling Shuai and Jin Jin and Yuanqiang Guo",

note = "Funding Information: This research was financially supported by the National Natural Science Foundation of China (Nos. U1703107 , U1801288 , and 21665013 ), the National Key Research and Development Program of China (No. 2018YFA0507204 ), Hundred Young Academic Leaders Program of Nankai University, State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University, No. CMEMR2018-B02 ), the Fundamental Research Funds for the Central Universities, Nankai University (Nos. 63191142 and 63191731 ), and the Natural Science Foundation of Tianjin (No. 16JCQNJC13500 ). Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

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doi = "10.1016/j.bioorg.2019.103237",

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AU - An, Lijun

AU - Liang, Yue

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AU - Wang, Huimei

AU - Zhang, Jie

AU - Tuerhong, Muhetaer

AU - Li, Dihua

AU - Wang, Chunyan

AU - Lee, Dongho

AU - Xu, Jing

AU - Shuai, Ling

AU - Jin, Jin

AU - Guo, Yuanqiang

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NO inhibitory diterpenoids as potential anti-inflammatory agents from Euphorbia antiquorum

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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