Non-convulsive seizure related to Cremophor EL™-free,polymeric micelle formulation of paclitaxel: A case report

Yoon Sun Shin, Kyung Jin Min, Seung Young Choi, Nak Woo Lee

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)

    Abstract

    Paclitaxel is a chemotherapeutic agent that is effective against ovarian, breast, lung, and other cancers. Although peripheral neurotoxicity is among the most common side effects of paclitaxel treatment, central neurotoxicity is rarely reported. When centrally mediated side effects are observed, they are attributed to Cremophor EL™ (CrEL), a surfactant-containing vehicle used for paclitaxel administration. In the present report, we discuss the case of a 72-yearold woman with ovarian carcinoma who experienced a non-convulsive seizure following administration of a CrELfree, polymeric micelle formulation of paclitaxel. One week after her fourth round of chemotherapy, she experienced a transient episode of aphasia for 45 minutes. Electroencephalography demonstrated epileptiform discharges. To our knowledge, this is the first reported case of seizure associated with a CrEL-free formulation of paclitaxel. Although rare, patients and clinicians should remain aware of the risk of non-convulsive seizure following infusion of this paclitaxel formulation.

    Original languageEnglish
    Pages (from-to)421-424
    Number of pages4
    JournalObstetrics and Gynecology Science
    Volume61
    Issue number3
    DOIs
    Publication statusPublished - 2018 May 1

    Keywords

    • Cremophor
    • Neurotoxicity
    • Paclitaxel
    • Seizures

    ASJC Scopus subject areas

    • Obstetrics and Gynaecology

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