Non-enzymatic glucose sensor based on cu electrode modified with CuO nanoflowers

A non-enzymatic glucose sensor was developed using copper oxide (CuO) nanoflower films on copper foil. Flower-shaped CuO nanostructures were synthesized directly by the hydrothermal oxidation of copper foil in an autoclave. The morphology of the CuO nanoflower film was characterized by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), and X-ray diffraction (XRD). The electrochemical performance of the electrode was studied by cyclic voltammetry (CV) and chronoamperometry. Glucose was oxidized directly at the CuO nanoflowers film under alkaline condition. The sensor exhibited a high sensitivity of 789.3 μA/mM · cm² (correlation coefficient R = 0.9961) at an applied potential of +0.5 V (vs. SCE) with a linear range of 9.54 × 10^-8 to 3.13 × 10 ^-3 M. It also showed a wide linear range, a low detection limit, good reproducibility, a long-term stability and excellent selectivity.