Abstract
Phytochemical investigation on the 70% aqueous EtOH extract from the roots of Patrinia scabra led to the isolation and characterization of five new non-glycosidic iridoids, patriscabrins F–J (1–5), along with a known iridoid 11-ethoxyviburtinal (6). The structures of the new compounds 1–5 were determined by interpretation of spectroscopic data, particularly by 1D- and 2D-NMR and ECD studies. Thereafter, the isolates 1–6 were evaluated for their inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells. Of these, patriscabrin F (1) exhibited the most potent inhibitory effect with observed IC50 value of 14.1 μM. In addition, patriscabrin G (2) and 11-ethoxyviburtinal (6) showed IC50 values 24.6 and 35.5 μM, respectively.
Original language | English |
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Pages (from-to) | 766-772 |
Number of pages | 7 |
Journal | Archives of pharmacal research |
Volume | 42 |
Issue number | 9 |
DOIs | |
Publication status | Published - 2019 Sept 1 |
Keywords
- Iridoid
- Nitric oxide
- Patrinia scabra
- Patriscabrin
- Valerianaceae
ASJC Scopus subject areas
- Molecular Medicine
- Drug Discovery
- Organic Chemistry