Non-invasive coronary physiology based on computational analysis of intracoronary transluminal attenuation gradient

Yong Gyun Bae, Seung Tae Hwang, Huan Han, Sung Mok Kim, Hyung Yoon Kim, Il Park, Joo Myung Lee, Young June Moon, Jin Ho Choi

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Invasive procedure is a prerequisite for studying coronary physiology. We established the measurement of non-invasive physiological parameters including coronary blood flow (CBF), flow velocity, and microvascular resistance using coronary computed tomography angiography (CCTA). Vessel-specific CBF was derived from transluminal attenuation flow encoding (TAFE) and then tested using three separate datasets consisted of computational simulation, human perfusion CT, and human CCTA. TAFE-derived CBF correlated well with measured vessel-specific myocardial blood flow and CBF. TAFE-derived CBF per myocardial mass consistently decreased with the progressive severity of stenosis, and it was found to better to detect significant stenosis than transluminal attenuation gradient (TAG). With the addition of vessel anatomy, TAFE-derived CBF could calculate flow velocity and microvascular resistance. The results of non-invasively acquired parameters according to the severity of stenosis were similar to those obtained through invasive physiology studies. Our study demonstrated that non-invasive comprehensive coronary physiology parameters can be derived from CCTA without any pre-specified condition or performing complex heavy computational processes. Our findings are expected to expand the clinical coverage of CCTA and coronary physiology.

Original languageEnglish
Article number4692
JournalScientific reports
Issue number1
Publication statusPublished - 2018 Dec 1

Bibliographical note

Funding Information:
This work was supported by National Research Foundation of Korea (2017R1A2B310918), Korean Circulation Society Research Fund (201301-01), Samsung Medical Center Clinical Research Project (OTC 1601861) and Heart Vascular and Stroke Institute.

Publisher Copyright:
© 2018 The Author(s).

ASJC Scopus subject areas

  • General


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