TY - JOUR
T1 - Noncovalent functionalization of carbon nanotubes for highly specific electronic biosensors
AU - Chen, Robert J.
AU - Bangsaruntip, Sarunya
AU - Drouvalakis, Katerina A.
AU - Wong Shi Kam, Nadine
AU - Shim, Moonsub
AU - Li, Yiming
AU - Kim, Woong
AU - Utz, Paul J.
AU - Dai, Hongjie
PY - 2003/4/29
Y1 - 2003/4/29
N2 - Novel nanomaterials for bioassay applications represent a rapidly progressing field of nanotechnology and nanobiotechnology. Here, we present an exploration of single-walled carbon nanotubes as a platform for investigating surface-protein and protein-protein binding and developing highly specific electronic biomolecule detectors. Nonspecific binding on nanotubes, a phenomenon found with a wide range of proteins, is overcome by immobilization of polyethylene oxide chains. A general approach is then advanced to enable the selective recognition and binding of target proteins by conjugation of their specific receptors to polyethylene oxide-functionalized nanotubes. This scheme, combined with the sensitivity of nanotube electronic devices, enables highly specific electronic sensors for detecting clinically important biomolecules such as antibodies associated with human autoimmune diseases.
AB - Novel nanomaterials for bioassay applications represent a rapidly progressing field of nanotechnology and nanobiotechnology. Here, we present an exploration of single-walled carbon nanotubes as a platform for investigating surface-protein and protein-protein binding and developing highly specific electronic biomolecule detectors. Nonspecific binding on nanotubes, a phenomenon found with a wide range of proteins, is overcome by immobilization of polyethylene oxide chains. A general approach is then advanced to enable the selective recognition and binding of target proteins by conjugation of their specific receptors to polyethylene oxide-functionalized nanotubes. This scheme, combined with the sensitivity of nanotube electronic devices, enables highly specific electronic sensors for detecting clinically important biomolecules such as antibodies associated with human autoimmune diseases.
UR - http://www.scopus.com/inward/record.url?scp=0037967030&partnerID=8YFLogxK
U2 - 10.1073/pnas.0837064100
DO - 10.1073/pnas.0837064100
M3 - Article
C2 - 12697899
AN - SCOPUS:0037967030
SN - 0027-8424
VL - 100
SP - 4984
EP - 4989
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 9
ER -
