Noncovalent functionalization of carbon nanotubes for highly specific electronic biosensors

Robert J. Chen, Sarunya Bangsaruntip, Katerina A. Drouvalakis, Nadine Wong Shi Kam, Moonsub Shim, Yiming Li, Woong Kim, Paul J. Utz, Hongjie Dai

Research output: Contribution to journalArticlepeer-review

1042 Citations (Scopus)


Novel nanomaterials for bioassay applications represent a rapidly progressing field of nanotechnology and nanobiotechnology. Here, we present an exploration of single-walled carbon nanotubes as a platform for investigating surface-protein and protein-protein binding and developing highly specific electronic biomolecule detectors. Nonspecific binding on nanotubes, a phenomenon found with a wide range of proteins, is overcome by immobilization of polyethylene oxide chains. A general approach is then advanced to enable the selective recognition and binding of target proteins by conjugation of their specific receptors to polyethylene oxide-functionalized nanotubes. This scheme, combined with the sensitivity of nanotube electronic devices, enables highly specific electronic sensors for detecting clinically important biomolecules such as antibodies associated with human autoimmune diseases.

Original languageEnglish
Pages (from-to)4984-4989
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number9
Publication statusPublished - 2003 Apr 29
Externally publishedYes

ASJC Scopus subject areas

  • General


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