Nonlinear finite-element analysis of the role of dynamic changes in blood perfusion and optical properties in laser coagulation of tissue

Beop Min Kim; Steven L. Jacques; Sohi Rastegar; Sharon Thomsen; Massoud Motamedi

doi:10.1109/2944.577317

Nonlinear finite-element analysis of the role of dynamic changes in blood perfusion and optical properties in laser coagulation of tissue

Beop Min Kim, Steven L. Jacques, Sohi Rastegar, Sharon Thomsen, Massoud Motamedi

Research output: Contribution to journal › Article › peer-review

126 Citations (Scopus)

Abstract

A nonlinear finite-element program was developed to simulate the dynamic evolution of coagulation in tissue considering temperature and damage dependence of both the optical properties and blood perfusion rate. These dynamic parameters were derived based on the Arrhenius rate process formulation of thermal damage and kinetics of vasodilation. Using this nonlinear model, we found that the region of increased blood flow that formed at the periphery of the coagulation region significantly reduces the heat penetration. Moreover, increased scattering in the near-surface region prevents light penetration into the deeper region. Therefore, if the dynamic parameters are ignored, a relatively significant overestimation of the temperature rise occurs in a deeper area resulting in an overestimation in predicted depth of coagulation. Mathematical modeling techniques that simulate laser coagulation may not provide reliable information unless they take into account these dynamic parameters.

Original language	English
Pages (from-to)	922-933
Number of pages	12
Journal	IEEE Journal on Selected Topics in Quantum Electronics
Volume	2
Issue number	4
DOIs	https://doi.org/10.1109/2944.577317
Publication status	Published - 1996 Dec

Bibliographical note

Funding Information:
This work was supported by the Department of Energy under Contract DE-FG03-95ER61971, by the National Institutes of Health under Contract R29-HL45045, by the Texas Advanced Technology Program 004952061, and by the Whitaker Foundation.

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics
Electrical and Electronic Engineering

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Cite this

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title = "Nonlinear finite-element analysis of the role of dynamic changes in blood perfusion and optical properties in laser coagulation of tissue",

abstract = "A nonlinear finite-element program was developed to simulate the dynamic evolution of coagulation in tissue considering temperature and damage dependence of both the optical properties and blood perfusion rate. These dynamic parameters were derived based on the Arrhenius rate process formulation of thermal damage and kinetics of vasodilation. Using this nonlinear model, we found that the region of increased blood flow that formed at the periphery of the coagulation region significantly reduces the heat penetration. Moreover, increased scattering in the near-surface region prevents light penetration into the deeper region. Therefore, if the dynamic parameters are ignored, a relatively significant overestimation of the temperature rise occurs in a deeper area resulting in an overestimation in predicted depth of coagulation. Mathematical modeling techniques that simulate laser coagulation may not provide reliable information unless they take into account these dynamic parameters.",

author = "Kim, {Beop Min} and Jacques, {Steven L.} and Sohi Rastegar and Sharon Thomsen and Massoud Motamedi",

note = "Funding Information: This work was supported by the Department of Energy under Contract DE-FG03-95ER61971, by the National Institutes of Health under Contract R29-HL45045, by the Texas Advanced Technology Program 004952061, and by the Whitaker Foundation.",

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AU - Kim, Beop Min

AU - Jacques, Steven L.

AU - Rastegar, Sohi

AU - Thomsen, Sharon

AU - Motamedi, Massoud

N1 - Funding Information: This work was supported by the Department of Energy under Contract DE-FG03-95ER61971, by the National Institutes of Health under Contract R29-HL45045, by the Texas Advanced Technology Program 004952061, and by the Whitaker Foundation.

PY - 1996/12

Y1 - 1996/12

N2 - A nonlinear finite-element program was developed to simulate the dynamic evolution of coagulation in tissue considering temperature and damage dependence of both the optical properties and blood perfusion rate. These dynamic parameters were derived based on the Arrhenius rate process formulation of thermal damage and kinetics of vasodilation. Using this nonlinear model, we found that the region of increased blood flow that formed at the periphery of the coagulation region significantly reduces the heat penetration. Moreover, increased scattering in the near-surface region prevents light penetration into the deeper region. Therefore, if the dynamic parameters are ignored, a relatively significant overestimation of the temperature rise occurs in a deeper area resulting in an overestimation in predicted depth of coagulation. Mathematical modeling techniques that simulate laser coagulation may not provide reliable information unless they take into account these dynamic parameters.

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Nonlinear finite-element analysis of the role of dynamic changes in blood perfusion and optical properties in laser coagulation of tissue

Abstract

Bibliographical note

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