Nontuberculous mycobacterial lung disease caused by mycobacterium simiae: The first reported case in South Korea

Suk Hyeon Jeong; Su Young Kim; Hyun Lee; Jun Soo Ham; Keum Bit Hwang; Subin Hwang; Sun Hye Shin; Myung Jin Chung; Seung Heon Lee; Sung Jae Shin; Won Jung Koh

doi:10.4046/trd.2015.78.4.432

Nontuberculous mycobacterial lung disease caused by mycobacterium simiae: The first reported case in South Korea

Suk Hyeon Jeong, Su Young Kim, Hyun Lee, Jun Soo Ham, Keum Bit Hwang, Subin Hwang, Sun Hye Shin, Myung Jin Chung, Seung Heon Lee, Sung Jae Shin, Won Jung Koh

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

This is a report of the first South Korean case of a lung disease caused by Mycobacterium simiae. The patient was a previously healthy 52-year-old female. All serial isolates were identified as M. simiae by multi-locus sequencing analysis, based on hsp65, rpoB, 16S-23S rRNA internal transcribed spacer, and 16S rRNA fragments. A chest radiography revealed deterioration, and the follow-up sputum cultures were persistently positive, despite combination antibiotic treatment, including azithromycin, ethambutol, and rifampin. To the best of our knowledge, this is the first confirmed case of a lung disease caused by M. simiae in South Korea.

Original language	English
Pages (from-to)	432-435
Number of pages	4
Journal	Tuberculosis and Respiratory Diseases
Volume	78
Issue number	4
DOIs	https://doi.org/10.4046/trd.2015.78.4.432
Publication status	Published - 2015 Oct 1
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by a grant of the Korean Health Technology R&D Project, Ministry for Health & Welfare, Republic of Korea (A120647) and by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2013R1A1A2060552).

Publisher Copyright:
Copyright © 2015 The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved.

Keywords

Bronchiectasis
Mycobacterium
Nontuberculous mycobacteria

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4046/trd.2015.78.4.432

Cite this

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title = "Nontuberculous mycobacterial lung disease caused by mycobacterium simiae: The first reported case in South Korea",

abstract = "This is a report of the first South Korean case of a lung disease caused by Mycobacterium simiae. The patient was a previously healthy 52-year-old female. All serial isolates were identified as M. simiae by multi-locus sequencing analysis, based on hsp65, rpoB, 16S-23S rRNA internal transcribed spacer, and 16S rRNA fragments. A chest radiography revealed deterioration, and the follow-up sputum cultures were persistently positive, despite combination antibiotic treatment, including azithromycin, ethambutol, and rifampin. To the best of our knowledge, this is the first confirmed case of a lung disease caused by M. simiae in South Korea.",

keywords = "Bronchiectasis, Mycobacterium, Nontuberculous mycobacteria",

author = "Jeong, {Suk Hyeon} and Kim, {Su Young} and Hyun Lee and Ham, {Jun Soo} and Hwang, {Keum Bit} and Subin Hwang and Shin, {Sun Hye} and Chung, {Myung Jin} and Lee, {Seung Heon} and Shin, {Sung Jae} and Koh, {Won Jung}",

note = "Funding Information: This work was supported by a grant of the Korean Health Technology R&D Project, Ministry for Health & Welfare, Republic of Korea (A120647) and by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2013R1A1A2060552). Publisher Copyright: Copyright {\textcopyright} 2015 The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved.",

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doi = "10.4046/trd.2015.78.4.432",

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T2 - The first reported case in South Korea

AU - Jeong, Suk Hyeon

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AU - Ham, Jun Soo

AU - Hwang, Keum Bit

AU - Hwang, Subin

AU - Shin, Sun Hye

AU - Chung, Myung Jin

AU - Lee, Seung Heon

AU - Shin, Sung Jae

AU - Koh, Won Jung

N1 - Funding Information: This work was supported by a grant of the Korean Health Technology R&D Project, Ministry for Health & Welfare, Republic of Korea (A120647) and by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2013R1A1A2060552). Publisher Copyright: Copyright © 2015 The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved.

PY - 2015/10/1

Y1 - 2015/10/1

N2 - This is a report of the first South Korean case of a lung disease caused by Mycobacterium simiae. The patient was a previously healthy 52-year-old female. All serial isolates were identified as M. simiae by multi-locus sequencing analysis, based on hsp65, rpoB, 16S-23S rRNA internal transcribed spacer, and 16S rRNA fragments. A chest radiography revealed deterioration, and the follow-up sputum cultures were persistently positive, despite combination antibiotic treatment, including azithromycin, ethambutol, and rifampin. To the best of our knowledge, this is the first confirmed case of a lung disease caused by M. simiae in South Korea.

AB - This is a report of the first South Korean case of a lung disease caused by Mycobacterium simiae. The patient was a previously healthy 52-year-old female. All serial isolates were identified as M. simiae by multi-locus sequencing analysis, based on hsp65, rpoB, 16S-23S rRNA internal transcribed spacer, and 16S rRNA fragments. A chest radiography revealed deterioration, and the follow-up sputum cultures were persistently positive, despite combination antibiotic treatment, including azithromycin, ethambutol, and rifampin. To the best of our knowledge, this is the first confirmed case of a lung disease caused by M. simiae in South Korea.

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KW - Mycobacterium

KW - Nontuberculous mycobacteria

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Nontuberculous mycobacterial lung disease caused by mycobacterium simiae: The first reported case in South Korea

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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