Notch-regulated perineurium development from zebrafish spinal cord

Ho Kim; Suhyun Kim; Ah Young Chung; Young Ki Bae; Masahiko Hibi; Chae Seung Lim; Hae Chul Park

doi:10.1016/j.neulet.2008.10.072

Notch-regulated perineurium development from zebrafish spinal cord

Ho Kim, Suhyun Kim, Ah Young Chung, Young Ki Bae, Masahiko Hibi, Chae Seung Lim, Hae Chul Park

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

In the developing central nervous system, nerve fascicles are surrounded by a protective sheath known as the perineurium. Perineurium is composed of perineurial cells that have both epithelial and myofibroblastoid properties, including tight and gap junctions and contractility. However, the molecular mechanism that governs perineurial development remains unclear. Here we focused on fabp7a, a brain lipid binding protein that is reportedly crucial for the proper differentiation of radial glial progenitor cells. Our study reveals that fabp7a is expressed in the lateral floor plate cells, and later perineurial glia in the spinal cord of zebrafish embryos. Furthermore, Notch signaling regulated perineurial glia development by maintaining fabp7a-expressing cells, demonstrating a novel mechanism for perineurial development.

Original language	English
Pages (from-to)	240-244
Number of pages	5
Journal	Neuroscience Letters
Volume	448
Issue number	3
DOIs	https://doi.org/10.1016/j.neulet.2008.10.072
Publication status	Published - 2008 Dec 31

Bibliographical note

Funding Information:
This work was supported by a grant (code A062520) from the Korea Health 21 R&D Project funded by Ministry of Health & Welfare, the Republic of Korea, and by a grant from the National Cancer Center, Korea (NCC-0810060-1), and Korea University grant.

Keywords

BLBP
Notch signaling
Perineurium
Radial glia
Spinal cord
Zebrafish

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neulet.2008.10.072

Cite this

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title = "Notch-regulated perineurium development from zebrafish spinal cord",

abstract = "In the developing central nervous system, nerve fascicles are surrounded by a protective sheath known as the perineurium. Perineurium is composed of perineurial cells that have both epithelial and myofibroblastoid properties, including tight and gap junctions and contractility. However, the molecular mechanism that governs perineurial development remains unclear. Here we focused on fabp7a, a brain lipid binding protein that is reportedly crucial for the proper differentiation of radial glial progenitor cells. Our study reveals that fabp7a is expressed in the lateral floor plate cells, and later perineurial glia in the spinal cord of zebrafish embryos. Furthermore, Notch signaling regulated perineurial glia development by maintaining fabp7a-expressing cells, demonstrating a novel mechanism for perineurial development.",

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author = "Ho Kim and Suhyun Kim and Chung, {Ah Young} and Bae, {Young Ki} and Masahiko Hibi and Lim, {Chae Seung} and Park, {Hae Chul}",

note = "Funding Information: This work was supported by a grant (code A062520) from the Korea Health 21 R&D Project funded by Ministry of Health & Welfare, the Republic of Korea, and by a grant from the National Cancer Center, Korea (NCC-0810060-1), and Korea University grant. ",

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AU - Kim, Suhyun

AU - Chung, Ah Young

AU - Bae, Young Ki

AU - Hibi, Masahiko

AU - Lim, Chae Seung

AU - Park, Hae Chul

N1 - Funding Information: This work was supported by a grant (code A062520) from the Korea Health 21 R&D Project funded by Ministry of Health & Welfare, the Republic of Korea, and by a grant from the National Cancer Center, Korea (NCC-0810060-1), and Korea University grant.

PY - 2008/12/31

Y1 - 2008/12/31

N2 - In the developing central nervous system, nerve fascicles are surrounded by a protective sheath known as the perineurium. Perineurium is composed of perineurial cells that have both epithelial and myofibroblastoid properties, including tight and gap junctions and contractility. However, the molecular mechanism that governs perineurial development remains unclear. Here we focused on fabp7a, a brain lipid binding protein that is reportedly crucial for the proper differentiation of radial glial progenitor cells. Our study reveals that fabp7a is expressed in the lateral floor plate cells, and later perineurial glia in the spinal cord of zebrafish embryos. Furthermore, Notch signaling regulated perineurial glia development by maintaining fabp7a-expressing cells, demonstrating a novel mechanism for perineurial development.

AB - In the developing central nervous system, nerve fascicles are surrounded by a protective sheath known as the perineurium. Perineurium is composed of perineurial cells that have both epithelial and myofibroblastoid properties, including tight and gap junctions and contractility. However, the molecular mechanism that governs perineurial development remains unclear. Here we focused on fabp7a, a brain lipid binding protein that is reportedly crucial for the proper differentiation of radial glial progenitor cells. Our study reveals that fabp7a is expressed in the lateral floor plate cells, and later perineurial glia in the spinal cord of zebrafish embryos. Furthermore, Notch signaling regulated perineurial glia development by maintaining fabp7a-expressing cells, demonstrating a novel mechanism for perineurial development.

KW - BLBP

KW - Notch signaling

KW - Perineurium

KW - Radial glia

KW - Spinal cord

KW - Zebrafish

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Notch-regulated perineurium development from zebrafish spinal cord

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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