Novel germline mutation of BRCA1 gene in a 56-Year-Old woman with breast cancer, ovarian cancer, and diffuse large B-Cell Lymphoma

Hye Sook Kim; Soon Wook Lee; Yoon Ji Choi; Sang Won Shin; Yeul Hong Kim; Min Sun Cho; Soon Nam Lee; Kyong Hwa Park

doi:10.4143/crt.2013.151

Novel germline mutation of BRCA1 gene in a 56-Year-Old woman with breast cancer, ovarian cancer, and diffuse large B-Cell Lymphoma

Hye Sook Kim, Soon Wook Lee, Yoon Ji Choi, Sang Won Shin, Yeul Hong Kim, Min Sun Cho, Soon Nam Lee, Kyong Hwa Park

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

We report a case of a 56-year-old woman with breast cancer, ovarian cancer, and diffuse large B-cell lymphoma with a BRCA1 gene mutation. Evidence is mounting that there is a large increase in the risk for hematologic malignancies among patients with genetic changes in the BRCA pathways. The genomic analysis demonstrated a frameshift mutation in the BRCA1 gene: 277_279delinsCC (Phe93fs). It is a novel BRCA1 mutation that has never been reported, and caused malignant lymphoma as well as breast and ovarian cancer.

Original language	English
Pages (from-to)	534-538
Number of pages	5
Journal	Cancer Research and Treatment
Volume	47
Issue number	3
DOIs	https://doi.org/10.4143/crt.2013.151
Publication status	Published - 2015

Bibliographical note

Publisher Copyright:
© 2015 by the Korean Cancer Association.

Keywords

BRCA1 gene
Breast neoplasms
Lymphoma
Ovarian neoplasms

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.4143/crt.2013.151

Cite this

@article{83150db1bb9f43a58ee79c11b006c638,

title = "Novel germline mutation of BRCA1 gene in a 56-Year-Old woman with breast cancer, ovarian cancer, and diffuse large B-Cell Lymphoma",

abstract = "We report a case of a 56-year-old woman with breast cancer, ovarian cancer, and diffuse large B-cell lymphoma with a BRCA1 gene mutation. Evidence is mounting that there is a large increase in the risk for hematologic malignancies among patients with genetic changes in the BRCA pathways. The genomic analysis demonstrated a frameshift mutation in the BRCA1 gene: 277_279delinsCC (Phe93fs). It is a novel BRCA1 mutation that has never been reported, and caused malignant lymphoma as well as breast and ovarian cancer.",

keywords = "BRCA1 gene, Breast neoplasms, Lymphoma, Ovarian neoplasms",

author = "Kim, {Hye Sook} and Lee, {Soon Wook} and Choi, {Yoon Ji} and Shin, {Sang Won} and Kim, {Yeul Hong} and Cho, {Min Sun} and Lee, {Soon Nam} and Park, {Kyong Hwa}",

note = "Publisher Copyright: {\textcopyright} 2015 by the Korean Cancer Association.",

year = "2015",

doi = "10.4143/crt.2013.151",

language = "English",

volume = "47",

pages = "534--538",

journal = "Cancer Research and Treatment",

issn = "1598-2998",

publisher = "Korean Cancer Association",

number = "3",

}

TY - JOUR

T1 - Novel germline mutation of BRCA1 gene in a 56-Year-Old woman with breast cancer, ovarian cancer, and diffuse large B-Cell Lymphoma

AU - Kim, Hye Sook

AU - Lee, Soon Wook

AU - Choi, Yoon Ji

AU - Shin, Sang Won

AU - Kim, Yeul Hong

AU - Cho, Min Sun

AU - Lee, Soon Nam

AU - Park, Kyong Hwa

PY - 2015

Y1 - 2015

N2 - We report a case of a 56-year-old woman with breast cancer, ovarian cancer, and diffuse large B-cell lymphoma with a BRCA1 gene mutation. Evidence is mounting that there is a large increase in the risk for hematologic malignancies among patients with genetic changes in the BRCA pathways. The genomic analysis demonstrated a frameshift mutation in the BRCA1 gene: 277_279delinsCC (Phe93fs). It is a novel BRCA1 mutation that has never been reported, and caused malignant lymphoma as well as breast and ovarian cancer.

AB - We report a case of a 56-year-old woman with breast cancer, ovarian cancer, and diffuse large B-cell lymphoma with a BRCA1 gene mutation. Evidence is mounting that there is a large increase in the risk for hematologic malignancies among patients with genetic changes in the BRCA pathways. The genomic analysis demonstrated a frameshift mutation in the BRCA1 gene: 277_279delinsCC (Phe93fs). It is a novel BRCA1 mutation that has never been reported, and caused malignant lymphoma as well as breast and ovarian cancer.

KW - BRCA1 gene

KW - Breast neoplasms

KW - Lymphoma

KW - Ovarian neoplasms

UR - http://www.scopus.com/inward/record.url?scp=84937148498&partnerID=8YFLogxK

U2 - 10.4143/crt.2013.151

DO - 10.4143/crt.2013.151

M3 - Article

AN - SCOPUS:84937148498

SN - 1598-2998

VL - 47

SP - 534

EP - 538

JO - Cancer Research and Treatment

JF - Cancer Research and Treatment

IS - 3

ER -

Novel germline mutation of BRCA1 gene in a 56-Year-Old woman with breast cancer, ovarian cancer, and diffuse large B-Cell Lymphoma

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this