TY - JOUR
T1 - Novel hydroxyapatite (HA) dual-scaffold with ultra-high porosity, high surface area, and compressive strength
AU - Jun, In Kook
AU - Koh, Young Hag
AU - Lee, Su Hee
AU - Kim, Hyoun Ee
N1 - Funding Information:
Acknowledgments This work was supported by a grant from the Korea Health 21 R&D Project, the ministry of Health & Welfare, Republic of Korea (02-PJ3-PG6EV11-0002).
PY - 2007/6
Y1 - 2007/6
N2 - A novel scaffold designed for tissue engineering applications, which we refer to as a "dual-scaffold" because its structure consists of two interlaced three-dimensional (3-D) hydroxyapatite (HA) networks, was fabricated using a combination of the rapid prototyping (RP) method and dip-coating process. To accomplish this, a graphite network acting as a template was prepared using the RP method and then uniformly dip-coated with HA slurry. The resultant sample was then heat-treated at 1250°C for 3 h in air to remove the graphite network and consolidate the HA networks. An additional 3-D channel was formed by removing the graphite network, while preserving the pre-existing channel. The unique structure of the dual-scaffold endows it with unprecedented features, such as ultra-high porosity (>85%), a high surface area and high compressive strength, as well as a tightly controlled pore structure. In addition, an excellent cellular response was observed to the fabricated HA dual-scaffold.
AB - A novel scaffold designed for tissue engineering applications, which we refer to as a "dual-scaffold" because its structure consists of two interlaced three-dimensional (3-D) hydroxyapatite (HA) networks, was fabricated using a combination of the rapid prototyping (RP) method and dip-coating process. To accomplish this, a graphite network acting as a template was prepared using the RP method and then uniformly dip-coated with HA slurry. The resultant sample was then heat-treated at 1250°C for 3 h in air to remove the graphite network and consolidate the HA networks. An additional 3-D channel was formed by removing the graphite network, while preserving the pre-existing channel. The unique structure of the dual-scaffold endows it with unprecedented features, such as ultra-high porosity (>85%), a high surface area and high compressive strength, as well as a tightly controlled pore structure. In addition, an excellent cellular response was observed to the fabricated HA dual-scaffold.
UR - http://www.scopus.com/inward/record.url?scp=34249029038&partnerID=8YFLogxK
U2 - 10.1007/s10856-007-0137-y
DO - 10.1007/s10856-007-0137-y
M3 - Article
C2 - 17268870
AN - SCOPUS:34249029038
SN - 0957-4522
VL - 18
SP - 1071
EP - 1077
JO - Journal of Materials Science: Materials in Electronics
JF - Journal of Materials Science: Materials in Electronics
IS - 6
ER -