Abstract
Paramyxoviruses harbored by multiple natural reservoirs pose a potential threat to public health. Jeilongvirus has been proposed as a novel paramyxovirus genus found in rodents, bats, and cats. Paramyxovirus RNA was detected in 108/824 (13.1%) Apodemus agrarius captured at 14 trapping sites in the Republic of Korea. We first present two genetically distinct novel paramyxoviruses, Paju Apodemus paramyxovirus 1 (PAPV-1) and 2 (PAPV-2). The disparity between PAPV-1 (19,716 nucleotides) and -2 (17,475 nucleotides) revealed the presence of the SH gene and length of the G gene in the genome organization. The phylogeny of PAPV-1 and -2 belonged to distinct genetic lineages of Jeilongvirus, respectively, even though these viruses were originated from A. agrarius. PAPV-1 infected human epithelial and endothelial cells, facilitating the induction of type I/III interferons, interferon-stimulated genes, and pro-inflammatory cytokines. Therefore, this study provides insights into the molecular epidemiology, genetic diversity, and virus-host interactions of novel rodent-borne paramyxoviruses.
| Original language | English |
|---|---|
| Pages (from-to) | 40-49 |
| Number of pages | 10 |
| Journal | Virology |
| Volume | 562 |
| DOIs | |
| Publication status | Published - 2021 Oct |
Bibliographical note
Funding Information:We thank Su-Am Kim and Hyebin Jeong for collecting wild small mammals and describing a figure, respectively. This research was supported by Basic Research Program through the National Research Foundation of Korea ( NRF ) funded by the Ministry of Education (NRF-2019R1I1A2A01060902). In addition, this work was supported by the Agency for Defense Development (UE202026GD). Partial funding was provided by the Armed Forces Health Surveillance Division Global Emerging Infections Surveillance Branch (GEIS), ProMIS ID P0039_18_ME. The views expressed in this article are those of the author and do not necessarily reflect the official policy or position of the Department of the Army, Department of Defense, or the U.S. Government. Authors, as employees of the U.S. Government (TAK, HCK), conducted the work as part of their official duties. Title 17 U.S.C. §105 provides that ‘Copyright protection under this title is not available for any work of the United States Government.’ Title 17 U.S.C. §101 defines a U.S. Government work is a work prepared by an employee of the U.S. Government as part of the person's official duties.
Funding Information:
We thank Su-Am Kim and Hyebin Jeong for collecting wild small mammals and describing a figure, respectively. This research was supported by Basic Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2019R1I1A2A01060902). In addition, this work was supported by the Agency for Defense Development (UE202026GD). Partial funding was provided by the Armed Forces Health Surveillance Division Global Emerging Infections Surveillance Branch (GEIS), ProMIS ID P0039_18_ME. The views expressed in this article are those of the author and do not necessarily reflect the official policy or position of the Department of the Army, Department of Defense, or the U.S. Government. Authors, as employees of the U.S. Government (TAK, HCK), conducted the work as part of their official duties. Title 17 U.S.C. §105 provides that ‘Copyright protection under this title is not available for any work of the United States Government.’ Title 17 U.S.C. §101 defines a U.S. Government work is a work prepared by an employee of the U.S. Government as part of the person's official duties.
Publisher Copyright:
© 2021
Keywords
- Apodemus agrarius
- Paju Apodemus paramyxovirus 1
- Paju Apodemus paramyxovirus 2
- Phylogenetic diversity
- Rodent paramyxovirus
ASJC Scopus subject areas
- Virology
