Novel Paju Apodemus paramyxovirus 1 and 2, harbored by Apodemus agrarius in the Republic of Korea

Seung Ho Lee, Jin Sun No, Kijin Kim, Shailesh Budhathoki, Kyungmin Park, Geum Young Lee, Seungchan Cho, Bong Hyun Kim, Seunghee Cho, Jongwoo Kim, Jingyeong Lee, Seung Hye Cho, Heung Chul Kim, Terry A. Klein, Chang Sub Uhm, Won Keun Kim, Jin Won Song

    Research output: Contribution to journalArticlepeer-review

    15 Citations (Scopus)

    Abstract

    Paramyxoviruses harbored by multiple natural reservoirs pose a potential threat to public health. Jeilongvirus has been proposed as a novel paramyxovirus genus found in rodents, bats, and cats. Paramyxovirus RNA was detected in 108/824 (13.1%) Apodemus agrarius captured at 14 trapping sites in the Republic of Korea. We first present two genetically distinct novel paramyxoviruses, Paju Apodemus paramyxovirus 1 (PAPV-1) and 2 (PAPV-2). The disparity between PAPV-1 (19,716 nucleotides) and -2 (17,475 nucleotides) revealed the presence of the SH gene and length of the G gene in the genome organization. The phylogeny of PAPV-1 and -2 belonged to distinct genetic lineages of Jeilongvirus, respectively, even though these viruses were originated from A. agrarius. PAPV-1 infected human epithelial and endothelial cells, facilitating the induction of type I/III interferons, interferon-stimulated genes, and pro-inflammatory cytokines. Therefore, this study provides insights into the molecular epidemiology, genetic diversity, and virus-host interactions of novel rodent-borne paramyxoviruses.

    Original languageEnglish
    Pages (from-to)40-49
    Number of pages10
    JournalVirology
    Volume562
    DOIs
    Publication statusPublished - 2021 Oct

    Bibliographical note

    Publisher Copyright:
    © 2021

    Keywords

    • Apodemus agrarius
    • Paju Apodemus paramyxovirus 1
    • Paju Apodemus paramyxovirus 2
    • Phylogenetic diversity
    • Rodent paramyxovirus

    ASJC Scopus subject areas

    • Virology

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