TY - JOUR
T1 - Novel Paju Apodemus paramyxovirus 1 and 2, harbored by Apodemus agrarius in the Republic of Korea
AU - Lee, Seung Ho
AU - No, Jin Sun
AU - Kim, Kijin
AU - Budhathoki, Shailesh
AU - Park, Kyungmin
AU - Lee, Geum Young
AU - Cho, Seungchan
AU - Kim, Bong Hyun
AU - Cho, Seunghee
AU - Kim, Jongwoo
AU - Lee, Jingyeong
AU - Cho, Seung Hye
AU - Kim, Heung Chul
AU - Klein, Terry A.
AU - Uhm, Chang Sub
AU - Kim, Won Keun
AU - Song, Jin Won
N1 - Publisher Copyright:
© 2021
PY - 2021/10
Y1 - 2021/10
N2 - Paramyxoviruses harbored by multiple natural reservoirs pose a potential threat to public health. Jeilongvirus has been proposed as a novel paramyxovirus genus found in rodents, bats, and cats. Paramyxovirus RNA was detected in 108/824 (13.1%) Apodemus agrarius captured at 14 trapping sites in the Republic of Korea. We first present two genetically distinct novel paramyxoviruses, Paju Apodemus paramyxovirus 1 (PAPV-1) and 2 (PAPV-2). The disparity between PAPV-1 (19,716 nucleotides) and -2 (17,475 nucleotides) revealed the presence of the SH gene and length of the G gene in the genome organization. The phylogeny of PAPV-1 and -2 belonged to distinct genetic lineages of Jeilongvirus, respectively, even though these viruses were originated from A. agrarius. PAPV-1 infected human epithelial and endothelial cells, facilitating the induction of type I/III interferons, interferon-stimulated genes, and pro-inflammatory cytokines. Therefore, this study provides insights into the molecular epidemiology, genetic diversity, and virus-host interactions of novel rodent-borne paramyxoviruses.
AB - Paramyxoviruses harbored by multiple natural reservoirs pose a potential threat to public health. Jeilongvirus has been proposed as a novel paramyxovirus genus found in rodents, bats, and cats. Paramyxovirus RNA was detected in 108/824 (13.1%) Apodemus agrarius captured at 14 trapping sites in the Republic of Korea. We first present two genetically distinct novel paramyxoviruses, Paju Apodemus paramyxovirus 1 (PAPV-1) and 2 (PAPV-2). The disparity between PAPV-1 (19,716 nucleotides) and -2 (17,475 nucleotides) revealed the presence of the SH gene and length of the G gene in the genome organization. The phylogeny of PAPV-1 and -2 belonged to distinct genetic lineages of Jeilongvirus, respectively, even though these viruses were originated from A. agrarius. PAPV-1 infected human epithelial and endothelial cells, facilitating the induction of type I/III interferons, interferon-stimulated genes, and pro-inflammatory cytokines. Therefore, this study provides insights into the molecular epidemiology, genetic diversity, and virus-host interactions of novel rodent-borne paramyxoviruses.
KW - Apodemus agrarius
KW - Paju Apodemus paramyxovirus 1
KW - Paju Apodemus paramyxovirus 2
KW - Phylogenetic diversity
KW - Rodent paramyxovirus
UR - http://www.scopus.com/inward/record.url?scp=85109672951&partnerID=8YFLogxK
U2 - 10.1016/j.virol.2021.06.011
DO - 10.1016/j.virol.2021.06.011
M3 - Article
C2 - 34256243
AN - SCOPUS:85109672951
SN - 0042-6822
VL - 562
SP - 40
EP - 49
JO - Virology
JF - Virology
ER -
