Abstract
Utilizing polymer-bound anthranilic acid derivatives, we were able to obtain 4-hydroxyquinolin-2(1H)-ones in 50-99% five-or six-step overall yields and 65-95% purities through the adaptation of a Dieckmann-type condensation reaction to a C-C bond-forming cyclative cleavage step. The reactions on solid phase were monitored by on-bead ATR-FTIR spectroscopic methods, colorimetric tests, and/or cleavage experiments.
Original language | English |
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Pages (from-to) | 1431-1435 |
Number of pages | 5 |
Journal | Synlett |
Issue number | 9 |
DOIs | |
Publication status | Published - 2007 Jun 1 |
Keywords
- Combinatorial chemistry
- Cyclative cleavage
- Dieckmann condensation
- Quinolinone
- Solid-phase synthesis
ASJC Scopus subject areas
- Organic Chemistry