Novel solid-phase synthetic method for combinatorial generation of a 4-hydroxyquinolin-2(1H)-one-based library

Moon Kook Jeon; Ju La Hyun; Deok Chan Ha; Young Dae Gong

doi:10.1055/s-2007-980368

Novel solid-phase synthetic method for combinatorial generation of a 4-hydroxyquinolin-2(1H)-one-based library

Moon Kook Jeon, Ju La Hyun, Deok Chan Ha, Young Dae Gong

College of Science

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Utilizing polymer-bound anthranilic acid derivatives, we were able to obtain 4-hydroxyquinolin-2(1H)-ones in 50-99% five-or six-step overall yields and 65-95% purities through the adaptation of a Dieckmann-type condensation reaction to a C-C bond-forming cyclative cleavage step. The reactions on solid phase were monitored by on-bead ATR-FTIR spectroscopic methods, colorimetric tests, and/or cleavage experiments.

Original language	English
Pages (from-to)	1431-1435
Number of pages	5
Journal	Synlett
Issue number	9
DOIs	https://doi.org/10.1055/s-2007-980368
Publication status	Published - 2007 Jun 1

Keywords

Combinatorial chemistry
Cyclative cleavage
Dieckmann condensation
Quinolinone
Solid-phase synthesis

ASJC Scopus subject areas

Organic Chemistry

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10.1055/s-2007-980368

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abstract = "Utilizing polymer-bound anthranilic acid derivatives, we were able to obtain 4-hydroxyquinolin-2(1H)-ones in 50-99% five-or six-step overall yields and 65-95% purities through the adaptation of a Dieckmann-type condensation reaction to a C-C bond-forming cyclative cleavage step. The reactions on solid phase were monitored by on-bead ATR-FTIR spectroscopic methods, colorimetric tests, and/or cleavage experiments.",

keywords = "Combinatorial chemistry, Cyclative cleavage, Dieckmann condensation, Quinolinone, Solid-phase synthesis",

author = "Jeon, {Moon Kook} and Hyun, {Ju La} and Ha, {Deok Chan} and Gong, {Young Dae}",

year = "2007",

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T1 - Novel solid-phase synthetic method for combinatorial generation of a 4-hydroxyquinolin-2(1H)-one-based library

AU - Jeon, Moon Kook

AU - Hyun, Ju La

AU - Ha, Deok Chan

AU - Gong, Young Dae

PY - 2007/6/1

Y1 - 2007/6/1

N2 - Utilizing polymer-bound anthranilic acid derivatives, we were able to obtain 4-hydroxyquinolin-2(1H)-ones in 50-99% five-or six-step overall yields and 65-95% purities through the adaptation of a Dieckmann-type condensation reaction to a C-C bond-forming cyclative cleavage step. The reactions on solid phase were monitored by on-bead ATR-FTIR spectroscopic methods, colorimetric tests, and/or cleavage experiments.

AB - Utilizing polymer-bound anthranilic acid derivatives, we were able to obtain 4-hydroxyquinolin-2(1H)-ones in 50-99% five-or six-step overall yields and 65-95% purities through the adaptation of a Dieckmann-type condensation reaction to a C-C bond-forming cyclative cleavage step. The reactions on solid phase were monitored by on-bead ATR-FTIR spectroscopic methods, colorimetric tests, and/or cleavage experiments.

KW - Combinatorial chemistry

KW - Cyclative cleavage

KW - Dieckmann condensation

KW - Quinolinone

KW - Solid-phase synthesis

UR - http://www.scopus.com/inward/record.url?scp=34250765381&partnerID=8YFLogxK

U2 - 10.1055/s-2007-980368

DO - 10.1055/s-2007-980368

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SP - 1431

EP - 1435

JO - Synlett

JF - Synlett

IS - 9

ER -

Novel solid-phase synthetic method for combinatorial generation of a 4-hydroxyquinolin-2(1H)-one-based library

Abstract

Keywords

ASJC Scopus subject areas

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