Nucleosides with modified sugar ring: Synthesis and biological activities

Sarbjit Singh; Deepak Bhattarai; Gajulapati Veeraswamy; Yongseok Choi; Kyeong Lee

doi:10.2174/1385272819666150803235458

Nucleosides with modified sugar ring: Synthesis and biological activities

Sarbjit Singh, Deepak Bhattarai, Gajulapati Veeraswamy, Yongseok Choi, Kyeong Lee

Research output: Contribution to journal › Review article › peer-review

11 Citations (Scopus)

Abstract

In the recent few years, the emergence of nucleosides containing modified sugar ring or modified base moiety has gained much attention due to their enhanced biological activities as compared to parent nucleosides containing 5-carbon ribose or deoxyribose sugar ring. In this review, we highlight the recent advances in synthesis and biological activities of nucleosides containing modified sugar rings reported between years 2010 to 2015.

Original language	English
Pages (from-to)	856-897
Number of pages	42
Journal	Current Organic Chemistry
Volume	20
Issue number	8
DOIs	https://doi.org/10.2174/1385272819666150803235458
Publication status	Published - 2016 Apr 1

Bibliographical note

Publisher Copyright:
© 2016 Bentham Science Publishers.

Keywords

Biologically active nucleosides
Fluorinated nucleosides
Functionalized nucleosides
Modified nucleosides
Selenonucleosides
Thionucleosides

ASJC Scopus subject areas

Organic Chemistry

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10.2174/1385272819666150803235458

Cite this

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abstract = "In the recent few years, the emergence of nucleosides containing modified sugar ring or modified base moiety has gained much attention due to their enhanced biological activities as compared to parent nucleosides containing 5-carbon ribose or deoxyribose sugar ring. In this review, we highlight the recent advances in synthesis and biological activities of nucleosides containing modified sugar rings reported between years 2010 to 2015.",

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AU - Singh, Sarbjit

AU - Bhattarai, Deepak

AU - Veeraswamy, Gajulapati

AU - Choi, Yongseok

AU - Lee, Kyeong

PY - 2016/4/1

Y1 - 2016/4/1

N2 - In the recent few years, the emergence of nucleosides containing modified sugar ring or modified base moiety has gained much attention due to their enhanced biological activities as compared to parent nucleosides containing 5-carbon ribose or deoxyribose sugar ring. In this review, we highlight the recent advances in synthesis and biological activities of nucleosides containing modified sugar rings reported between years 2010 to 2015.

AB - In the recent few years, the emergence of nucleosides containing modified sugar ring or modified base moiety has gained much attention due to their enhanced biological activities as compared to parent nucleosides containing 5-carbon ribose or deoxyribose sugar ring. In this review, we highlight the recent advances in synthesis and biological activities of nucleosides containing modified sugar rings reported between years 2010 to 2015.

KW - Biologically active nucleosides

KW - Fluorinated nucleosides

KW - Functionalized nucleosides

KW - Modified nucleosides

KW - Selenonucleosides

KW - Thionucleosides

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JO - Current Organic Chemistry

JF - Current Organic Chemistry

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Nucleosides with modified sugar ring: Synthesis and biological activities

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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