Nucleosides with modified sugar ring: Synthesis and biological activities

Sarbjit Singh; Deepak Bhattarai; Gajulapati Veeraswamy; Yongseok Choi; Kyeong Lee

Nucleosides with modified sugar ring: Synthesis and biological activities

Sarbjit Singh, Deepak Bhattarai, Gajulapati Veeraswamy, Yongseok Choi, Kyeong Lee

Department of Biotechnology

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

In the recent few years, the emergence of nucleosides containing modified sugar ring or modified base moiety has gained much attention due to their enhanced biological activities as compared to parent nucleosides containing 5-carbon ribose or deoxyribose sugar ring. In this review, we highlight the recent advances in synthesis and biological activities of nucleosides containing modified sugar rings reported between years 2010 to 2015.

Original language	English
Pages (from-to)	856-897
Number of pages	42
Journal	Current Organic Chemistry
Volume	20
Issue number	8
Publication status	Published - 2016 Apr 1

Keywords

Biologically active nucleosides
Fluorinated nucleosides
Functionalized nucleosides
Modified nucleosides
Selenonucleosides
Thionucleosides

ASJC Scopus subject areas

Organic Chemistry

Cite this

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abstract = "In the recent few years, the emergence of nucleosides containing modified sugar ring or modified base moiety has gained much attention due to their enhanced biological activities as compared to parent nucleosides containing 5-carbon ribose or deoxyribose sugar ring. In this review, we highlight the recent advances in synthesis and biological activities of nucleosides containing modified sugar rings reported between years 2010 to 2015.",

keywords = "Biologically active nucleosides, Fluorinated nucleosides, Functionalized nucleosides, Modified nucleosides, Selenonucleosides, Thionucleosides",

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AU - Singh, Sarbjit

AU - Bhattarai, Deepak

AU - Veeraswamy, Gajulapati

AU - Choi, Yongseok

AU - Lee, Kyeong

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N2 - In the recent few years, the emergence of nucleosides containing modified sugar ring or modified base moiety has gained much attention due to their enhanced biological activities as compared to parent nucleosides containing 5-carbon ribose or deoxyribose sugar ring. In this review, we highlight the recent advances in synthesis and biological activities of nucleosides containing modified sugar rings reported between years 2010 to 2015.

AB - In the recent few years, the emergence of nucleosides containing modified sugar ring or modified base moiety has gained much attention due to their enhanced biological activities as compared to parent nucleosides containing 5-carbon ribose or deoxyribose sugar ring. In this review, we highlight the recent advances in synthesis and biological activities of nucleosides containing modified sugar rings reported between years 2010 to 2015.

KW - Biologically active nucleosides

KW - Fluorinated nucleosides

KW - Functionalized nucleosides

KW - Modified nucleosides

KW - Selenonucleosides

KW - Thionucleosides

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ER -

Nucleosides with modified sugar ring: Synthesis and biological activities

Abstract

Keywords

ASJC Scopus subject areas

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