Obesity prevalence has increased in the last decades worldwide leading to metabolic complications, such as type 2 diabetes, steatosis, cardiovascular disease, among others; its development is influenced by genetic factors and environmental factors, such as intestinal microbiome. In Mexico, 33.3% of the adults present this disease. Obesity is defined as an excessive adipose tissue accumulation, provoking its dysfunction. Adipose tissue remodeling, which involves angiogenesis, hypoxia and inflammation, is implicated in the developing of obesity and metabolic modifications. Bariatric surgery is the most used and successful intervention to control morbid obesity, leading a maintained loss of weight and remission of some of its comorbidities as type 2 diabetes. Here, we review some of the molecular aspects of the metabolic changes provoked by bariatric surgery and its impact in weight loss and comorbidities remission. In summary, this article reviews the genetic aspects, microbiome and molecular facts (adipose tissue remodeling) that are involved in obesity development. In addition, some of the molecular aspects about bariatric surgery are described and the mechanisms that are regulated to control obesity and its comorbidities.
|Translated title of the contribution||Obesity, adipose tissue, and bariatric surgery|
|Number of pages||12|
|Journal||Boletin Medico del Hospital Infantil de Mexico|
|Publication status||Published - 2020 Jan 1|
Bibliographical noteFunding Information:
CONACYT-NRF 2016 proyecto No. 278791, PAPI-IT-DGAPA-UNAM proyecto No. IA203919, HIM-2018-028FF SSA1494, IBM Mexico, National Research Foundation of Korea (NRF-2016K2A9A1A06945430), Basic Science Research Program through the National Research Foundation of Korea (2017R1D1A1B03031216).
© 2019 Hospital Infantil de México Federico Gómez.
- Adipose tissue
- Bariatric surgery
- Gastric bypass
- Sleeve gastrectomy
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health