Abstract
Background: The aim of this study was to investigate the prevalence of obesity in Korean men with Klinefelter syndrome (KS) and the associated risk factors for obesity and hyperglycemia. Methods: Data were collected retrospectively from medical records from 11 university hospitals in Korea between 1994 and 2014. Subjects aged ≥18 years with newly diagnosed KS were enrolled. The following parameters were recorded at baseline before treatment: chief complaint, height, weight, fasting glucose level, lipid panel, blood pressure, testosterone, luteinizing hormone, follicle-stimulating hormone, karyotyping patterns, and history of hypertension, diabetes, and dyslipidemia. Results: Data were analyzed from 376 of 544 initially enrolled patients. The rate of the 47 XXY chromosomal pattern was 94.1%. The prevalence of obesity (body mass index ≥25 kg/m2) in Korean men with KS was 42.6%. The testosterone level was an independent risk factor for obesity and hyperglycemia. Conclusion: Obesity is common in Korean men with KS. Hypogonadism in patients with KS was associated with obesity and hyperglycemia.
Original language | English |
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Pages (from-to) | 598-603 |
Number of pages | 6 |
Journal | Endocrinology and Metabolism |
Volume | 31 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2016 |
Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2016 Korean Endocrine Society.
Keywords
- Hyperglycemia
- Klinefelter syndrome
- Obesity
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Endocrinology