Obesity and hyperglycemia in Korean men with klinefelter syndrome: The Korean endocrine society registry

Seung Jin Han, Kyung Soo Kim, Wonjin Kim, Jung Hee Kim, Yong Ho Lee, Ji Sun Nam, Ji A. Seo, Bu Kyung Kim, Jihyun Lee, Jin Ook Chung, Min Hee Kim, Tae Seo Sohn, Han Seok Choi, Seong Bin Hong, Yoon Sok Chung

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)


Background: The aim of this study was to investigate the prevalence of obesity in Korean men with Klinefelter syndrome (KS) and the associated risk factors for obesity and hyperglycemia. Methods: Data were collected retrospectively from medical records from 11 university hospitals in Korea between 1994 and 2014. Subjects aged ≥18 years with newly diagnosed KS were enrolled. The following parameters were recorded at baseline before treatment: chief complaint, height, weight, fasting glucose level, lipid panel, blood pressure, testosterone, luteinizing hormone, follicle-stimulating hormone, karyotyping patterns, and history of hypertension, diabetes, and dyslipidemia. Results: Data were analyzed from 376 of 544 initially enrolled patients. The rate of the 47 XXY chromosomal pattern was 94.1%. The prevalence of obesity (body mass index ≥25 kg/m2) in Korean men with KS was 42.6%. The testosterone level was an independent risk factor for obesity and hyperglycemia. Conclusion: Obesity is common in Korean men with KS. Hypogonadism in patients with KS was associated with obesity and hyperglycemia.

Original languageEnglish
Pages (from-to)598-603
Number of pages6
JournalEndocrinology and Metabolism
Issue number4
Publication statusPublished - 2016
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2016 Korean Endocrine Society.


  • Hyperglycemia
  • Klinefelter syndrome
  • Obesity

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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