Obesity and risk factors for cardiovascular disease and type 2 diabetes: Investigating the role of physical activity and sedentary behaviour in mid-life in the 1958 British cohort

Chris Power, Snehal M. Pinto Pereira, Catherine Law, Myung Ki

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

Objective: A key public health priority is to minimise obesity-related health consequences. We aim to establish whether physical activity (PA) or less sedentary behaviour ameliorate associations of obesity with biomarkers for cardiovascular disease (CVD) and type 2 diabetes. Methods: Data on obesity (33. y), PA (42. y), TV-viewing and health biomarkers (45. y) are from the 1958 British birth cohort (N= 9377). Results: Obesity was associated with an adverse biomarker profile for CVD and type 2 diabetes. For PA, men active ≥1/week had 1.09% (0.28, 1.90) lower diastolic blood pressure (DBP) than less active men; triglycerides were 2.08% (0.52, 3.64) lower per unit higher PA (on 4-point scale). TV-viewing was independently associated with several biomarkers, e.g. per unit higher TV-viewing (on 4-point scale) DBP was raised by 0.50% (0.09, 0.90) and triglycerides by 3.61% (1.58, 5.64). For both TV-viewing and PA, associations with HbA1c were greatest for the obese (pinteraction≤0.04): compared to a reference value of 5.20 HbA1c% in non-obese men viewing 0-1h/day, HbA1c% differed little for those viewing >3h/day; among obese men HbA1c% was 5.36 (5.22, 5.51) and 5.65 (5.53, 5.76), for 0-1 and >3h/day respectively. For PA in non-obese men, the reduction associated with activity ≥1/week was negligible compared to a reference value of 5.20 HbA1c% for those less active; but there was a reduction among obese men, HbA1c% was 5.50 (5.40, 5.59) vs 5.66 (5.55, 5.77) respectively. Conclusion: Reduced TV-viewing and prevention of infrequent activity have greatest beneficial associations for glucose metabolism among the obese, with benefits for other biomarkers across obese and non-obese groups.

Original languageEnglish
Pages (from-to)363-369
Number of pages7
JournalAtherosclerosis
Volume233
Issue number2
DOIs
Publication statusPublished - 2014 Apr
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by the Department of Health Policy Research Programme through the Public Health Research Consortium (PHRC). The views expressed in the publication are those of the authors and not necessarily those of the Department of Health. The funders had no role in the study design; collection, analysis and interpretation of data; in writing the report; and in the decision to submit the article for publication. Information about the wider programme of the PHRC is available from y biomedical survey (grant: http://phrc.lshtm.ac.uk . The Medical Research Council funded the 45 G0000934 ). The GOSH/UCL Institute of Child Health was supported in part by the Department of Health's NIHR Biomedical Research Centre.

Keywords

  • Body mass index
  • Cardiovascular diseases
  • Glucose metabolism
  • Physical activity
  • Sedentary behaviour
  • TV-viewing

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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