Obviously Enhanced Fluorescent Signal of Core-Shell Nanostructures through Simultaneous Regulation of Spectral Overlap and Shell Thickness for Imaging and Photothermal Therapy of Ovarian Cancer Cells

Xianyang Li; Jingyuan Huang; Xin Wu; Xianling Piao; Danning Lv; Gude Zhang; Dong June Ahn; Chunzhi Cui

doi:10.1002/ppsc.202300083

Obviously Enhanced Fluorescent Signal of Core-Shell Nanostructures through Simultaneous Regulation of Spectral Overlap and Shell Thickness for Imaging and Photothermal Therapy of Ovarian Cancer Cells

Xianyang Li, Jingyuan Huang, Xin Wu, Xianling Piao, Danning Lv, Gude Zhang, Dong June Ahn, Chunzhi Cui

Department of Chemical and Biological Engineering

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

In this research, by simultaneously regulating the two major factors affecting the plasmonic enhanced fluorescence (PEF), spectral overlap and the distance between the fluororophores and the noble metal nanoparticles, a significantly enhanced fluorescent signal is achieved. Core-shell nanostructures composed of aspect ratio (AR) adjustable gold nanorods (GNRs) and various thickness of SiO₂ are prepared and the decorated fluorophores are realized optimized PEF. A typical stimuli-responsive conjugated polymer, polydiacetylene (PDA), and a near-infrared (NIR) dye Cy5.5 are selected as fluorophores and their fluorescent signal are enhanced 7.26 and 4.41 times, respectively. Based on the optimized optical properties, a multifunctional antibody modified Mab-Cy5.5-GNRs@SiO₂ is successfully demonstrated the targeting, imaging, and photothermal therapy (PTT) effects on SKOV-3 ovarian cancer cells.

Original language	English
Article number	2300083
Journal	Particle and Particle Systems Characterization
Volume	40
Issue number	12
DOIs	https://doi.org/10.1002/ppsc.202300083
Publication status	Published - 2023 Dec

Bibliographical note

Publisher Copyright:
© 2023 Wiley-VCH GmbH.

Keywords

gold nanorods
photothermal therapy
plasmon-enhanced fluorescence

ASJC Scopus subject areas

General Chemistry
General Materials Science
Condensed Matter Physics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/ppsc.202300083

Cite this

Li, X., Huang, J., Wu, X., Piao, X., Lv, D., Zhang, G., Ahn, D. J., & Cui, C. (2023). Obviously Enhanced Fluorescent Signal of Core-Shell Nanostructures through Simultaneous Regulation of Spectral Overlap and Shell Thickness for Imaging and Photothermal Therapy of Ovarian Cancer Cells. Particle and Particle Systems Characterization, 40(12), Article 2300083. https://doi.org/10.1002/ppsc.202300083

Obviously Enhanced Fluorescent Signal of Core-Shell Nanostructures through Simultaneous Regulation of Spectral Overlap and Shell Thickness for Imaging and Photothermal Therapy of Ovarian Cancer Cells. / Li, Xianyang; Huang, Jingyuan; Wu, Xin et al.
In: Particle and Particle Systems Characterization, Vol. 40, No. 12, 2300083, 12.2023.

Research output: Contribution to journal › Article › peer-review

Li, X, Huang, J, Wu, X, Piao, X, Lv, D, Zhang, G, Ahn, DJ & Cui, C 2023, 'Obviously Enhanced Fluorescent Signal of Core-Shell Nanostructures through Simultaneous Regulation of Spectral Overlap and Shell Thickness for Imaging and Photothermal Therapy of Ovarian Cancer Cells', Particle and Particle Systems Characterization, vol. 40, no. 12, 2300083. https://doi.org/10.1002/ppsc.202300083

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abstract = "In this research, by simultaneously regulating the two major factors affecting the plasmonic enhanced fluorescence (PEF), spectral overlap and the distance between the fluororophores and the noble metal nanoparticles, a significantly enhanced fluorescent signal is achieved. Core-shell nanostructures composed of aspect ratio (AR) adjustable gold nanorods (GNRs) and various thickness of SiO2 are prepared and the decorated fluorophores are realized optimized PEF. A typical stimuli-responsive conjugated polymer, polydiacetylene (PDA), and a near-infrared (NIR) dye Cy5.5 are selected as fluorophores and their fluorescent signal are enhanced 7.26 and 4.41 times, respectively. Based on the optimized optical properties, a multifunctional antibody modified Mab-Cy5.5-GNRs@SiO2 is successfully demonstrated the targeting, imaging, and photothermal therapy (PTT) effects on SKOV-3 ovarian cancer cells.",

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AU - Lv, Danning

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AB - In this research, by simultaneously regulating the two major factors affecting the plasmonic enhanced fluorescence (PEF), spectral overlap and the distance between the fluororophores and the noble metal nanoparticles, a significantly enhanced fluorescent signal is achieved. Core-shell nanostructures composed of aspect ratio (AR) adjustable gold nanorods (GNRs) and various thickness of SiO2 are prepared and the decorated fluorophores are realized optimized PEF. A typical stimuli-responsive conjugated polymer, polydiacetylene (PDA), and a near-infrared (NIR) dye Cy5.5 are selected as fluorophores and their fluorescent signal are enhanced 7.26 and 4.41 times, respectively. Based on the optimized optical properties, a multifunctional antibody modified Mab-Cy5.5-GNRs@SiO2 is successfully demonstrated the targeting, imaging, and photothermal therapy (PTT) effects on SKOV-3 ovarian cancer cells.

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Obviously Enhanced Fluorescent Signal of Core-Shell Nanostructures through Simultaneous Regulation of Spectral Overlap and Shell Thickness for Imaging and Photothermal Therapy of Ovarian Cancer Cells

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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