On Training Deep 3D CNN Models with Dependent Samples in Neuroimaging

Yunyang Xiong, Hyunwoo J. Kim, Bhargav Tangirala, Ronak Mehta, Sterling C. Johnson, Vikas Singh

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)


There is much interest in developing algorithms based on 3D convolutional neural networks (CNNs) for performing regression and classification with brain imaging data and more generally, with biomedical imaging data. A standard assumption in learning is that the training samples are independently drawn from the underlying distribution. In computer vision, where we have millions of training examples, this assumption is violated but the empirical performance may remain satisfactory. But in many biomedical studies with just a few hundred training examples, one often has multiple samples per participant and/or data may be curated by pooling datasets from a few different institutions. Here, the violation of the independent samples assumption turns out to be more significant, especially in small-to-medium sized datasets. Motivated by this need, we show how 3D CNNs can be modified to deal with dependent samples. We show that even with standard 3D CNNs, there is value in augmenting the network to exploit information regarding dependent samples. We present empirical results for predicting cognitive trajectories (slope and intercept) from morphometric change images derived from multiple time points. With terms which encode dependency between samples in the model, we get consistent improvements over a strong baseline which ignores such knowledge.

Original languageEnglish
Title of host publicationInformation Processing in Medical Imaging - 26th International Conference, IPMI 2019, Proceedings
EditorsSiqi Bao, Albert C.S. Chung, James C. Gee, Paul A. Yushkevich
PublisherSpringer Verlag
Number of pages13
ISBN (Print)9783030203504
Publication statusPublished - 2019
Event26th International Conference on Information Processing in Medical Imaging, IPMI 2019 - Hong Kong, China
Duration: 2019 Jun 22019 Jun 7

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume11492 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349


Conference26th International Conference on Information Processing in Medical Imaging, IPMI 2019
CityHong Kong

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)


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