One-dimensional nanomaterials for cancer therapy and diagnosis

Jinwoo Shin, Nayeon Kang, Byungkook Kim, Hyunsik Hong, Le Yu, Jungryun Kim, Heemin Kang, Jong Seung Kim

Research output: Contribution to journalReview articlepeer-review

9 Citations (Scopus)

Abstract

One-dimensional (1-D) nanomaterials possess unique shape-dependent phyicochemical properties and are increasingly recognized as promising materials for nanotechnology. 1-D nanomaterials can be classified according to their shape, such as nanorods, nanotubes, nanowires, self-assembled nanochains, etc., and have been applied in electronics, photonics, and catalysis. The biological characteristics of 1-D nanomaterials, including high drug loading efficiency, prolonged blood circulation, the ability to capture cancer cells, unique cellular uptake mechanisms, efficient photothermal conversion, and material tunability, have aided in extending their potential to biomedical applications, particularly in cancer therapy and diagnosis. This review highlights a novel perspective on emerging 1-D nanomaterials for cancer therapy and diagnosis by introducing the definition of 1-D nanomaterials, their shape-dependent physicochemical properties, biomedical applications, and recent advances in cancer therapy and diagnosis. This review also proposes unexplored potential nanomaterial types and therapeutic applications for 1-D nanomaterials. In particular, the most significant and exciting advances in recent years, including ultrasound-enabled sonodynamic therapy, magnetic field-based therapy, and bioresponsive 1-D nanomaterials for intracellular self-assembly in situ, are discussed along with novel therapeutic concepts, such as piezoelectric 1-D nanomaterials, nanozyme-based nanomedicine, and others.

Original languageEnglish
Pages (from-to)4488-4514
Number of pages27
JournalChemical Society Reviews
Volume52
Issue number13
DOIs
Publication statusPublished - 2023 Jun 20

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (no. RS-2023-00208427, H. Kang; and CRI project no. 2018R1A3B1052702 and NRF-2019M3E5D1A01068998, J. S. Kim).

Publisher Copyright:
© 2023 The Royal Society of Chemistry.

ASJC Scopus subject areas

  • General Chemistry

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