Open-closed switching of synthetic tubular pores

Yongju Kim, Jiheong Kang, Bowen Shen, Yanqiu Wang, Ying He, Myongsoo Lee

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)


While encouraging progress has been made on switchable nanopores to mimic biological channels and pores, it remains a great challenge to realize long tubular pores with a dynamic open-closed motion. Here we report μm-long, dynamic tubular pores that undergo rapid switching between open and closed states in response to a thermal signal in water. The tubular walls consist of laterally associated primary fibrils stacked from disc-shaped molecules in which the discs readily tilt by means of thermally regulated dehydration of the oligoether chains placed on the wall surfaces. Notably, this pore switching mediates a controlled water-pumping catalytic action for the dehydrative cyclization of adenosine monophosphate to produce metabolically active cyclic adenosine monophosphate. We believe that our work may allow the creation of a variety of dynamic pore structures with complex functions arising from open-closed motion.

Original languageEnglish
Article number8650
JournalNature communications
Publication statusPublished - 2015 Oct 12
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)


Dive into the research topics of 'Open-closed switching of synthetic tubular pores'. Together they form a unique fingerprint.

Cite this