Abstract
We present a new, sensitive, few mode fiber (FMF) surface plasmon resonance (SPR) biosensor with a sandwich assay for the detection of PSA. The side-polished FMF biosensor does not need a polarizer and a thin high-index overlayer. The optical sensitivity of the SPR sensor was determined as 2.5 × 10-6 RIU. In the SPR PSA sensor, the SPR signals were amplified by a factor of 6 in average over no secondary antibody, using the sandwich assay. The proposed FMF SPR biosensor has great potential for real-time analysis of immune reaction between biomolecules and the advantages of high-sensitivity and label-free detection.
Original language | English |
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Pages (from-to) | 2827-2830 |
Number of pages | 4 |
Journal | Optics Communications |
Volume | 282 |
Issue number | 14 |
DOIs | |
Publication status | Published - 2009 Jul 15 |
Externally published | Yes |
Keywords
- Biosensor
- Detection
- Optical fiber sensor
- Surface plasmon resonance (SPR)
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Atomic and Molecular Physics, and Optics
- Physical and Theoretical Chemistry
- Electrical and Electronic Engineering