Optimal antimicrobial therapy and antimicrobial stewardship in sepsis and septic shock

Hyeri Seok, Dae Won Park

    Research output: Contribution to journalArticlepeer-review

    1 Citation (Scopus)


    The management of sepsis and septic shock remains challenging. The aim is to apply the optimal antimicrobial therapy and antimicrobial stewardship to patients in state of sepsis or septic shock. To reduce the mortality of sepsis and septic shock, it is critical to promptly administer the appropriate antibiotics with an accurate diagnosis. De-escalation is needed 48 to 72 hours after the first administration of antibiotics depending on the findings of causative pathogens. In the case of antibiotic resistance, the importance of an antibiotic stewardship program is increasingly being emphasized. Antimicrobial stewardship implies coordinated interventions designed to improve the appropriate use of antibiotics by promoting the selection of an optimal drug regimen such as dosing, duration of therapy, and route of administration. An antibiotic stewardship program may also be applied to patients of both sepsis and septic shock. Efforts such as the selection of appropriate empirical antibiotics, de-escalation, and determination of whether to stop antibiotics with procalcitonin may improve the clinical prognosis of patients with sepsis as well as the successful implementation of an antibiotic stewardship program.

    Original languageEnglish
    Pages (from-to)638-644
    Number of pages7
    JournalJournal of the Korean Medical Association
    Issue number12
    Publication statusPublished - 2019 Jan 1


    • Anti-bacterial agents
    • Anti-infective agents
    • Antibiotic stewardship
    • Sepsis
    • Septic shock

    ASJC Scopus subject areas

    • General Medicine


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