TY - GEN
T1 - Optimal estimation in DNA microarrays via global optimization
AU - Lee, Sang Hyun
AU - Shamaiah, Manohar
AU - Vikalo, Haris
PY - 2010
Y1 - 2010
N2 - DNA microarray technology relies on affinity between complementary nucleic acids to detect the presence and estimate the amounts of target molecules of interest. Molecular binding is stochastic in nature, having inherent uncertainty manifested as Poisson noise. This, along with interference due to non-specific binding, are among the main obstacles for achieving high accuracy of DNA microarrays. In this paper, optimal target estimation in DNA microarrays is shown to lead to a fractional program. A practically feasible approach which employs a branch-and-bound algorithm solving a convex optimization problem in each step is presented. Simulation results demonstrate that the proposed approach outperforms previously considered methods.
AB - DNA microarray technology relies on affinity between complementary nucleic acids to detect the presence and estimate the amounts of target molecules of interest. Molecular binding is stochastic in nature, having inherent uncertainty manifested as Poisson noise. This, along with interference due to non-specific binding, are among the main obstacles for achieving high accuracy of DNA microarrays. In this paper, optimal target estimation in DNA microarrays is shown to lead to a fractional program. A practically feasible approach which employs a branch-and-bound algorithm solving a convex optimization problem in each step is presented. Simulation results demonstrate that the proposed approach outperforms previously considered methods.
KW - DNA microarray
KW - fractional programming
KW - global optimization
UR - http://www.scopus.com/inward/record.url?scp=79957988225&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79957988225&partnerID=8YFLogxK
U2 - 10.1109/ACSSC.2010.5757844
DO - 10.1109/ACSSC.2010.5757844
M3 - Conference contribution
AN - SCOPUS:79957988225
SN - 9781424497218
T3 - Conference Record - Asilomar Conference on Signals, Systems and Computers
SP - 1765
EP - 1769
BT - Conference Record of the 44th Asilomar Conference on Signals, Systems and Computers, Asilomar 2010
T2 - 44th Asilomar Conference on Signals, Systems and Computers, Asilomar 2010
Y2 - 7 November 2010 through 10 November 2010
ER -