TY - JOUR
T1 - Optimal production of 7,10-epoxy-octadeca-7,9-dienoic acid from 7,10-dihydroxy-8(E)-octadecenoic acid by heat treatment
AU - Ellamar, Joel B.
AU - Kim, In Hwan
AU - Hou, Ching T.
AU - Kim, Hak Ryul
N1 - Funding Information:
This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education ( 2018R1D1A3B07040443 ).
Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2020/3
Y1 - 2020/3
N2 - Furan fatty acids (F-acid) are known to have strong antioxidant properties, including radical scavenging activity, which play important roles in biological systems including humans. F-acids are widely distributed in most biological systems as trace components and their biosyntheses are complicated. Although several studies were reported on the chemical synthesis of various types of F-acids, it required complicated and multistep chemical reactions. Recently, a simple one-step heat treatment method was developed for the production of a novel furan fatty acid, 7,10-epoxy-octadeca-7,9-dienoic acid (7,10-EODA) from 7,10-dihydroxy-8(E)-octadecenoic acid (DOD). (Journal of Agricultural and Food Chemistry, 2011, 59, 8175–8179). In this report, we optimized reaction conditions for the efficient production of 7,10-EODA from DOD by heat treatment. Under optimal conditions tested, the maximum production yield of 7,10-EODA was 80% with incubation in hexane for at least 48 h at 85 °C or above.
AB - Furan fatty acids (F-acid) are known to have strong antioxidant properties, including radical scavenging activity, which play important roles in biological systems including humans. F-acids are widely distributed in most biological systems as trace components and their biosyntheses are complicated. Although several studies were reported on the chemical synthesis of various types of F-acids, it required complicated and multistep chemical reactions. Recently, a simple one-step heat treatment method was developed for the production of a novel furan fatty acid, 7,10-epoxy-octadeca-7,9-dienoic acid (7,10-EODA) from 7,10-dihydroxy-8(E)-octadecenoic acid (DOD). (Journal of Agricultural and Food Chemistry, 2011, 59, 8175–8179). In this report, we optimized reaction conditions for the efficient production of 7,10-EODA from DOD by heat treatment. Under optimal conditions tested, the maximum production yield of 7,10-EODA was 80% with incubation in hexane for at least 48 h at 85 °C or above.
KW - 7,10-Dihydroxy-8(E)-octadecenoic acid
KW - 7,10-Epoxy-octadeca-7,9-dienoic acid
KW - Furan fatty acid
KW - Heat treatment
UR - http://www.scopus.com/inward/record.url?scp=85080085112&partnerID=8YFLogxK
U2 - 10.1016/j.bcab.2020.101545
DO - 10.1016/j.bcab.2020.101545
M3 - Article
AN - SCOPUS:85080085112
SN - 1878-8181
VL - 24
JO - Biocatalysis and Agricultural Biotechnology
JF - Biocatalysis and Agricultural Biotechnology
M1 - 101545
ER -