Optimal production of 7,10-epoxy-octadeca-7,9-dienoic acid from 7,10-dihydroxy-8(E)-octadecenoic acid by heat treatment

Joel B. Ellamar, In Hwan Kim, Ching T. Hou, Hak Ryul Kim

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Furan fatty acids (F-acid) are known to have strong antioxidant properties, including radical scavenging activity, which play important roles in biological systems including humans. F-acids are widely distributed in most biological systems as trace components and their biosyntheses are complicated. Although several studies were reported on the chemical synthesis of various types of F-acids, it required complicated and multistep chemical reactions. Recently, a simple one-step heat treatment method was developed for the production of a novel furan fatty acid, 7,10-epoxy-octadeca-7,9-dienoic acid (7,10-EODA) from 7,10-dihydroxy-8(E)-octadecenoic acid (DOD). (Journal of Agricultural and Food Chemistry, 2011, 59, 8175–8179). In this report, we optimized reaction conditions for the efficient production of 7,10-EODA from DOD by heat treatment. Under optimal conditions tested, the maximum production yield of 7,10-EODA was 80% with incubation in hexane for at least 48 h at 85 °C or above.

Original languageEnglish
Article number101545
JournalBiocatalysis and Agricultural Biotechnology
Publication statusPublished - 2020 Mar

Bibliographical note

Funding Information:
This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education ( 2018R1D1A3B07040443 ).

Publisher Copyright:
© 2020 Elsevier Ltd


  • 7,10-Dihydroxy-8(E)-octadecenoic acid
  • 7,10-Epoxy-octadeca-7,9-dienoic acid
  • Furan fatty acid
  • Heat treatment

ASJC Scopus subject areas

  • Biotechnology
  • Food Science
  • Bioengineering
  • Applied Microbiology and Biotechnology
  • Agronomy and Crop Science


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