Optimal standing-wave design of nonlinear simulated moving bed systems for enantioseparation

Ki Bong Lee, Sungyong Mun, Fattaneh Cauley, Geoffrey B. Cox, Nien Hwa Linda Wang

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


An efficient optimization tool is developed based on the standing-wave design for simulated moving bed (SMB) systems with nonlinear isotherms and significant mass-transfer effects. A maximum operating pressure is considered in the optimization. Both system parameters (particle size, column length, column diameter, total number of columns, column configuration, and feed concentration) and operating parameters (zone flow rates and switching time) are optimized to achieve the maximum productivity or the minimum separation cost. Under a pressure limit, medium particle size (10-40μm), short columns (5-15 cm), and a longer zone II give higher productivity and lower separation cost. Nonlinear effects resulting from high feed concentration can decrease productivity and increase separation cost. High-pressure SMB systems (5.2 MPa) can have higher productivity, but low- and medium-pressure SMB systems (1.0 and 2.4 MPa, respectively) are more economical.

Original languageEnglish
Pages (from-to)739-752
Number of pages14
JournalIndustrial and Engineering Chemistry Research
Issue number2
Publication statusPublished - 2006 Jan 18
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Industrial and Manufacturing Engineering


Dive into the research topics of 'Optimal standing-wave design of nonlinear simulated moving bed systems for enantioseparation'. Together they form a unique fingerprint.

Cite this