Optimization of feed conditions in a 2.5-l fed-batch culture using rice oil to improve cephalosporin C production by Cephalosporium acremonium M25

Ri Kim Na; Soo Lim Jung; In Hong Suk; Wook Kim Seung

doi:10.1007/s11274-004-3852-2

Optimization of feed conditions in a 2.5-l fed-batch culture using rice oil to improve cephalosporin C production by Cephalosporium acremonium M25

Ri Kim Na, Soo Lim Jung, In Hong Suk, Wook Kim Seung

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Rice oil significantly affected cephalosporin C production in a 2.5-l bioreactor culture of Cephalosporium acremonium M25. To improve cephalosporin C production, the feed conditions of rice oil were optimized. Reducing the feed rate of rice oil improved cephalosporin C production to 1.01 g/l when the consumption rate of rice oil decreased. Overall, under optimal feed conditions in the 2.5-l fed-batch culture, cephalosporin C production increased about four times compared to before optimization.

Original language	English
Pages (from-to)	787-789
Number of pages	3
Journal	World Journal of Microbiology and Biotechnology
Volume	21
Issue number	5
DOIs	https://doi.org/10.1007/s11274-004-3852-2
Publication status	Published - 2005 Jul

Bibliographical note

Funding Information:
This study was supported by research grants from the Korea Science and Engineering Foundation (KOSEF) through the Applied Rheology Center (ARC), an official KOSEF-created engineering research center (ERC) at Korea University, Seoul, Korea.

Keywords

Cephalosporin C
Cephalosporium acremonium
Fed-batch
Feed conditions
Rice oil

ASJC Scopus subject areas

Biotechnology
Physiology
Applied Microbiology and Biotechnology

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10.1007/s11274-004-3852-2

Cite this

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title = "Optimization of feed conditions in a 2.5-l fed-batch culture using rice oil to improve cephalosporin C production by Cephalosporium acremonium M25",

abstract = "Rice oil significantly affected cephalosporin C production in a 2.5-l bioreactor culture of Cephalosporium acremonium M25. To improve cephalosporin C production, the feed conditions of rice oil were optimized. Reducing the feed rate of rice oil improved cephalosporin C production to 1.01 g/l when the consumption rate of rice oil decreased. Overall, under optimal feed conditions in the 2.5-l fed-batch culture, cephalosporin C production increased about four times compared to before optimization.",

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author = "Na, {Ri Kim} and Jung, {Soo Lim} and Suk, {In Hong} and Seung, {Wook Kim}",

note = "Funding Information: This study was supported by research grants from the Korea Science and Engineering Foundation (KOSEF) through the Applied Rheology Center (ARC), an official KOSEF-created engineering research center (ERC) at Korea University, Seoul, Korea.",

year = "2005",

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doi = "10.1007/s11274-004-3852-2",

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AU - Jung, Soo Lim

AU - Suk, In Hong

AU - Seung, Wook Kim

N1 - Funding Information: This study was supported by research grants from the Korea Science and Engineering Foundation (KOSEF) through the Applied Rheology Center (ARC), an official KOSEF-created engineering research center (ERC) at Korea University, Seoul, Korea.

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Y1 - 2005/7

N2 - Rice oil significantly affected cephalosporin C production in a 2.5-l bioreactor culture of Cephalosporium acremonium M25. To improve cephalosporin C production, the feed conditions of rice oil were optimized. Reducing the feed rate of rice oil improved cephalosporin C production to 1.01 g/l when the consumption rate of rice oil decreased. Overall, under optimal feed conditions in the 2.5-l fed-batch culture, cephalosporin C production increased about four times compared to before optimization.

AB - Rice oil significantly affected cephalosporin C production in a 2.5-l bioreactor culture of Cephalosporium acremonium M25. To improve cephalosporin C production, the feed conditions of rice oil were optimized. Reducing the feed rate of rice oil improved cephalosporin C production to 1.01 g/l when the consumption rate of rice oil decreased. Overall, under optimal feed conditions in the 2.5-l fed-batch culture, cephalosporin C production increased about four times compared to before optimization.

KW - Cephalosporin C

KW - Cephalosporium acremonium

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KW - Feed conditions

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Optimization of feed conditions in a 2.5-l fed-batch culture using rice oil to improve cephalosporin C production by Cephalosporium acremonium M25

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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