Optimization of temperature swing strategy for selective cooling crystallization of α-form l-glutamic acid crystals

Seungjong Yeom, Huichan Yun, Dae Ryook Yang

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

l-glutamic acid can be crystallized as metastable α-form and stable β-form crystal. The α-form is desired because of its prismatic shape. Production of α-form of l-glutamic acid by cooling crystallization is not well-defined and α-form solid is commercially not available. In this study, an optimal cooling strategy to selectively produce large and narrowly distributed α-crystals is found by modeling and optimizing the crystallization and polymorphic transformation of l-glutamic acid. The optimal temperature profile is found to be cooling-heating-cooling concept where short nucleation period is followed by growth period in metastable zone. The obtained α-form of L-glutamic acid by optimal strategy had improved mean size, distribution, and purity compared to constant cooling.

Original languageEnglish
Pages (from-to)1836-1842
Number of pages7
JournalKorean Journal of Chemical Engineering
Volume30
Issue number10
DOIs
Publication statusPublished - 2013 Oct

Bibliographical note

Funding Information:
This work was supported by the Human Resources Development program (No. 20114010203070) of the Korea Institute of Energy Technology Evaluation and Planning (KETEP) grant funded by the Korea government Ministry of Trade, Industry and Energy.

Keywords

  • Cooling Crystallization
  • Optimization
  • Polymorphic Transformation
  • Population Balance Model
  • l-Glutamic Acid

ASJC Scopus subject areas

  • General Chemistry
  • General Chemical Engineering

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