Optimization of temperature swing strategy for selective cooling crystallization of α-form l-glutamic acid crystals

Seungjong Yeom; Huichan Yun; Dae Ryook Yang

doi:10.1007/s11814-013-0124-6

Optimization of temperature swing strategy for selective cooling crystallization of α-form l-glutamic acid crystals

Seungjong Yeom, Huichan Yun, Dae Ryook Yang

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

l-glutamic acid can be crystallized as metastable α-form and stable β-form crystal. The α-form is desired because of its prismatic shape. Production of α-form of l-glutamic acid by cooling crystallization is not well-defined and α-form solid is commercially not available. In this study, an optimal cooling strategy to selectively produce large and narrowly distributed α-crystals is found by modeling and optimizing the crystallization and polymorphic transformation of l-glutamic acid. The optimal temperature profile is found to be cooling-heating-cooling concept where short nucleation period is followed by growth period in metastable zone. The obtained α-form of L-glutamic acid by optimal strategy had improved mean size, distribution, and purity compared to constant cooling.

Original language	English
Pages (from-to)	1836-1842
Number of pages	7
Journal	Korean Journal of Chemical Engineering
Volume	30
Issue number	10
DOIs	https://doi.org/10.1007/s11814-013-0124-6
Publication status	Published - 2013 Oct

Bibliographical note

Funding Information:
This work was supported by the Human Resources Development program (No. 20114010203070) of the Korea Institute of Energy Technology Evaluation and Planning (KETEP) grant funded by the Korea government Ministry of Trade, Industry and Energy.

Keywords

Cooling Crystallization
Optimization
Polymorphic Transformation
Population Balance Model
l-Glutamic Acid

ASJC Scopus subject areas

General Chemistry
General Chemical Engineering

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10.1007/s11814-013-0124-6

Cite this

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title = "Optimization of temperature swing strategy for selective cooling crystallization of α-form l-glutamic acid crystals",

abstract = "l-glutamic acid can be crystallized as metastable α-form and stable β-form crystal. The α-form is desired because of its prismatic shape. Production of α-form of l-glutamic acid by cooling crystallization is not well-defined and α-form solid is commercially not available. In this study, an optimal cooling strategy to selectively produce large and narrowly distributed α-crystals is found by modeling and optimizing the crystallization and polymorphic transformation of l-glutamic acid. The optimal temperature profile is found to be cooling-heating-cooling concept where short nucleation period is followed by growth period in metastable zone. The obtained α-form of L-glutamic acid by optimal strategy had improved mean size, distribution, and purity compared to constant cooling.",

keywords = "Cooling Crystallization, Optimization, Polymorphic Transformation, Population Balance Model, l-Glutamic Acid",

author = "Seungjong Yeom and Huichan Yun and Yang, {Dae Ryook}",

note = "Funding Information: This work was supported by the Human Resources Development program (No. 20114010203070) of the Korea Institute of Energy Technology Evaluation and Planning (KETEP) grant funded by the Korea government Ministry of Trade, Industry and Energy.",

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doi = "10.1007/s11814-013-0124-6",

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AU - Yeom, Seungjong

AU - Yun, Huichan

AU - Yang, Dae Ryook

N1 - Funding Information: This work was supported by the Human Resources Development program (No. 20114010203070) of the Korea Institute of Energy Technology Evaluation and Planning (KETEP) grant funded by the Korea government Ministry of Trade, Industry and Energy.

PY - 2013/10

Y1 - 2013/10

N2 - l-glutamic acid can be crystallized as metastable α-form and stable β-form crystal. The α-form is desired because of its prismatic shape. Production of α-form of l-glutamic acid by cooling crystallization is not well-defined and α-form solid is commercially not available. In this study, an optimal cooling strategy to selectively produce large and narrowly distributed α-crystals is found by modeling and optimizing the crystallization and polymorphic transformation of l-glutamic acid. The optimal temperature profile is found to be cooling-heating-cooling concept where short nucleation period is followed by growth period in metastable zone. The obtained α-form of L-glutamic acid by optimal strategy had improved mean size, distribution, and purity compared to constant cooling.

AB - l-glutamic acid can be crystallized as metastable α-form and stable β-form crystal. The α-form is desired because of its prismatic shape. Production of α-form of l-glutamic acid by cooling crystallization is not well-defined and α-form solid is commercially not available. In this study, an optimal cooling strategy to selectively produce large and narrowly distributed α-crystals is found by modeling and optimizing the crystallization and polymorphic transformation of l-glutamic acid. The optimal temperature profile is found to be cooling-heating-cooling concept where short nucleation period is followed by growth period in metastable zone. The obtained α-form of L-glutamic acid by optimal strategy had improved mean size, distribution, and purity compared to constant cooling.

KW - Cooling Crystallization

KW - Optimization

KW - Polymorphic Transformation

KW - Population Balance Model

KW - l-Glutamic Acid

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SP - 1836

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JO - Korean Journal of Chemical Engineering

JF - Korean Journal of Chemical Engineering

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Optimization of temperature swing strategy for selective cooling crystallization of α-form l-glutamic acid crystals

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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