Optofluidic surface enhanced Raman scattering chip for detection of dengue virus

Suk Huh Yun; Aram J. Chung; Bernardo Cordovez; David Erickson

doi:10.1115/IMECE2008-67243

Optofluidic surface enhanced Raman scattering chip for detection of dengue virus

Suk Huh Yun
, Aram J. Chung
, Bernardo Cordovez
, David Erickson

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

In this work we describe the development of an optofluidic device for surface enhanced Raman scattering (SERS) based detection of biological pathogens. The chip exploits the use of electro-active microwells which serve to both physically concentrate the Raman enhancers and to reduce the total analysis time through a unique electrokinetically driven on-chip mixing effect. To quantify the concentralion performance of the device we use 44 nm polystyrene particles at low electric field strength (between 1.00-2.00 V) and demonstrate close to 90% concentration saturation within 2.5 s. We demonstrate the mixing capability through the enhanced detection of dengue virus serotype 2 (DENV-2). With DENV-2, we successfully detected the SERS signals with a limit of detection of 30 pM.

Original language	English
Title of host publication	2008 Proceedings of ASME International Mechanical Engineering Congress and Exposition, IMECE 2008
Pages	873-876
Number of pages	4
Edition	PART B
DOIs	https://doi.org/10.1115/IMECE2008-67243
Publication status	Published - 2009
Externally published	Yes
Event	2008 ASME International Mechanical Engineering Congress and Exposition, IMECE 2008 - Boston, MA, United States Duration: 2008 Oct 31 → 2008 Nov 6

Publication series

Name	ASME International Mechanical Engineering Congress and Exposition, Proceedings
Number	PART B
Volume	13

Other

Other	2008 ASME International Mechanical Engineering Congress and Exposition, IMECE 2008
Country/Territory	United States
City	Boston, MA
Period	08/10/31 → 08/11/6

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Mechanical Engineering

Access to Document

10.1115/IMECE2008-67243

Cite this

Yun, S. H., Chung, A. J., Cordovez, B., & Erickson, D. (2009). Optofluidic surface enhanced Raman scattering chip for detection of dengue virus. In 2008 Proceedings of ASME International Mechanical Engineering Congress and Exposition, IMECE 2008 (PART B ed., pp. 873-876). (ASME International Mechanical Engineering Congress and Exposition, Proceedings; Vol. 13, No. PART B). https://doi.org/10.1115/IMECE2008-67243

Optofluidic surface enhanced Raman scattering chip for detection of dengue virus. / Yun, Suk Huh; Chung, Aram J.; Cordovez, Bernardo et al.
2008 Proceedings of ASME International Mechanical Engineering Congress and Exposition, IMECE 2008. PART B. ed. 2009. p. 873-876 (ASME International Mechanical Engineering Congress and Exposition, Proceedings; Vol. 13, No. PART B).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Yun, SH, Chung, AJ, Cordovez, B & Erickson, D 2009, Optofluidic surface enhanced Raman scattering chip for detection of dengue virus. in 2008 Proceedings of ASME International Mechanical Engineering Congress and Exposition, IMECE 2008. PART B edn, ASME International Mechanical Engineering Congress and Exposition, Proceedings, no. PART B, vol. 13, pp. 873-876, 2008 ASME International Mechanical Engineering Congress and Exposition, IMECE 2008, Boston, MA, United States, 08/10/31. https://doi.org/10.1115/IMECE2008-67243

Yun SH, Chung AJ, Cordovez B, Erickson D. Optofluidic surface enhanced Raman scattering chip for detection of dengue virus. In 2008 Proceedings of ASME International Mechanical Engineering Congress and Exposition, IMECE 2008. PART B ed. 2009. p. 873-876. (ASME International Mechanical Engineering Congress and Exposition, Proceedings; PART B). doi: 10.1115/IMECE2008-67243

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abstract = "In this work we describe the development of an optofluidic device for surface enhanced Raman scattering (SERS) based detection of biological pathogens. The chip exploits the use of electro-active microwells which serve to both physically concentrate the Raman enhancers and to reduce the total analysis time through a unique electrokinetically driven on-chip mixing effect. To quantify the concentralion performance of the device we use 44 nm polystyrene particles at low electric field strength (between 1.00-2.00 V) and demonstrate close to 90\% concentration saturation within 2.5 s. We demonstrate the mixing capability through the enhanced detection of dengue virus serotype 2 (DENV-2). With DENV-2, we successfully detected the SERS signals with a limit of detection of 30 pM.",

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AB - In this work we describe the development of an optofluidic device for surface enhanced Raman scattering (SERS) based detection of biological pathogens. The chip exploits the use of electro-active microwells which serve to both physically concentrate the Raman enhancers and to reduce the total analysis time through a unique electrokinetically driven on-chip mixing effect. To quantify the concentralion performance of the device we use 44 nm polystyrene particles at low electric field strength (between 1.00-2.00 V) and demonstrate close to 90% concentration saturation within 2.5 s. We demonstrate the mixing capability through the enhanced detection of dengue virus serotype 2 (DENV-2). With DENV-2, we successfully detected the SERS signals with a limit of detection of 30 pM.

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Optofluidic surface enhanced Raman scattering chip for detection of dengue virus

Abstract

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UN SDGs

ASJC Scopus subject areas

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