Oral administration of Astragalus membranaceus inhibits the development of DNFB-induced dermatitis in NC/Nga mice

Su Jin Lee; Seung Geun Oh; Sang Wan Seo; Hyun Jong Ahn; Dongho Geum; Jeong Je Cho; Cheung Seog Park

doi:10.1248/bpb.30.1468

Oral administration of Astragalus membranaceus inhibits the development of DNFB-induced dermatitis in NC/Nga mice

Su Jin Lee, Seung Geun Oh, Sang Wan Seo, Hyun Jong Ahn, Dongho Geum, Jeong Je Cho, Cheung Seog Park

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

Epicutaneously administered chemical antigens like 2,4-dinitrofluorobenzene (DNFB), evoke an atopic dermatitis (AD)-like dermatitis reaction in NC/Nga mice under specific pathogen free (SPF) conditions. Astragalus membranaceus (AM), is a popular herbal medicine used to treat allergic diseases in East Asia. In the present study, we examined whether AM suppress AD-like skin lesions in NC/Nga mice treated with DNFB under SPF conditions. Oral administration of AM to DNFB-treated NC/Nga mice was found to inhibit ear thickness increases and the skin lesions induced by DNFB. Moreover, IFN-γ production by CD4 ⁺ T cells from the lymph nodes of DNFB-treated NC/Nga mice was significantly inhibited by AM treatment, although levels of IL-4 and total IgE in serum were not. Study findings suggest that AM may suppress the development of AD-like dermatitis in DNFB-treated NC/Nga mice by reducing IFN-γ production.

Original language	English
Pages (from-to)	1468-1471
Number of pages	4
Journal	Biological and Pharmaceutical Bulletin
Volume	30
Issue number	8
DOIs	https://doi.org/10.1248/bpb.30.1468
Publication status	Published - 2007 Aug

Keywords

2,4-dinitrofluorobenzene (DNFB)
Astragalus membranaceus
Atopic dermatitis
NC/Nga mice

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

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10.1248/bpb.30.1468

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title = "Oral administration of Astragalus membranaceus inhibits the development of DNFB-induced dermatitis in NC/Nga mice",

abstract = "Epicutaneously administered chemical antigens like 2,4-dinitrofluorobenzene (DNFB), evoke an atopic dermatitis (AD)-like dermatitis reaction in NC/Nga mice under specific pathogen free (SPF) conditions. Astragalus membranaceus (AM), is a popular herbal medicine used to treat allergic diseases in East Asia. In the present study, we examined whether AM suppress AD-like skin lesions in NC/Nga mice treated with DNFB under SPF conditions. Oral administration of AM to DNFB-treated NC/Nga mice was found to inhibit ear thickness increases and the skin lesions induced by DNFB. Moreover, IFN-γ production by CD4 + T cells from the lymph nodes of DNFB-treated NC/Nga mice was significantly inhibited by AM treatment, although levels of IL-4 and total IgE in serum were not. Study findings suggest that AM may suppress the development of AD-like dermatitis in DNFB-treated NC/Nga mice by reducing IFN-γ production.",

keywords = "2,4-dinitrofluorobenzene (DNFB), Astragalus membranaceus, Atopic dermatitis, NC/Nga mice",

author = "Lee, {Su Jin} and Oh, {Seung Geun} and Seo, {Sang Wan} and Ahn, {Hyun Jong} and Dongho Geum and Cho, {Jeong Je} and Park, {Cheung Seog}",

year = "2007",

month = aug,

doi = "10.1248/bpb.30.1468",

language = "English",

volume = "30",

pages = "1468--1471",

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AU - Lee, Su Jin

AU - Oh, Seung Geun

AU - Seo, Sang Wan

AU - Ahn, Hyun Jong

AU - Geum, Dongho

AU - Cho, Jeong Je

AU - Park, Cheung Seog

PY - 2007/8

Y1 - 2007/8

N2 - Epicutaneously administered chemical antigens like 2,4-dinitrofluorobenzene (DNFB), evoke an atopic dermatitis (AD)-like dermatitis reaction in NC/Nga mice under specific pathogen free (SPF) conditions. Astragalus membranaceus (AM), is a popular herbal medicine used to treat allergic diseases in East Asia. In the present study, we examined whether AM suppress AD-like skin lesions in NC/Nga mice treated with DNFB under SPF conditions. Oral administration of AM to DNFB-treated NC/Nga mice was found to inhibit ear thickness increases and the skin lesions induced by DNFB. Moreover, IFN-γ production by CD4 + T cells from the lymph nodes of DNFB-treated NC/Nga mice was significantly inhibited by AM treatment, although levels of IL-4 and total IgE in serum were not. Study findings suggest that AM may suppress the development of AD-like dermatitis in DNFB-treated NC/Nga mice by reducing IFN-γ production.

AB - Epicutaneously administered chemical antigens like 2,4-dinitrofluorobenzene (DNFB), evoke an atopic dermatitis (AD)-like dermatitis reaction in NC/Nga mice under specific pathogen free (SPF) conditions. Astragalus membranaceus (AM), is a popular herbal medicine used to treat allergic diseases in East Asia. In the present study, we examined whether AM suppress AD-like skin lesions in NC/Nga mice treated with DNFB under SPF conditions. Oral administration of AM to DNFB-treated NC/Nga mice was found to inhibit ear thickness increases and the skin lesions induced by DNFB. Moreover, IFN-γ production by CD4 + T cells from the lymph nodes of DNFB-treated NC/Nga mice was significantly inhibited by AM treatment, although levels of IL-4 and total IgE in serum were not. Study findings suggest that AM may suppress the development of AD-like dermatitis in DNFB-treated NC/Nga mice by reducing IFN-γ production.

KW - 2,4-dinitrofluorobenzene (DNFB)

KW - Astragalus membranaceus

KW - Atopic dermatitis

KW - NC/Nga mice

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Oral administration of Astragalus membranaceus inhibits the development of DNFB-induced dermatitis in NC/Nga mice

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