Oral administration of Astragalus membranaceus inhibits the development of DNFB-induced dermatitis in NC/Nga mice

Su Jin Lee, Seung Geun Oh, Sang Wan Seo, Hyun Jong Ahn, Dongho Geum, Jeong Je Cho, Cheung Seog Park

    Research output: Contribution to journalArticlepeer-review

    42 Citations (Scopus)

    Abstract

    Epicutaneously administered chemical antigens like 2,4-dinitrofluorobenzene (DNFB), evoke an atopic dermatitis (AD)-like dermatitis reaction in NC/Nga mice under specific pathogen free (SPF) conditions. Astragalus membranaceus (AM), is a popular herbal medicine used to treat allergic diseases in East Asia. In the present study, we examined whether AM suppress AD-like skin lesions in NC/Nga mice treated with DNFB under SPF conditions. Oral administration of AM to DNFB-treated NC/Nga mice was found to inhibit ear thickness increases and the skin lesions induced by DNFB. Moreover, IFN-γ production by CD4 + T cells from the lymph nodes of DNFB-treated NC/Nga mice was significantly inhibited by AM treatment, although levels of IL-4 and total IgE in serum were not. Study findings suggest that AM may suppress the development of AD-like dermatitis in DNFB-treated NC/Nga mice by reducing IFN-γ production.

    Original languageEnglish
    Pages (from-to)1468-1471
    Number of pages4
    JournalBiological and Pharmaceutical Bulletin
    Volume30
    Issue number8
    DOIs
    Publication statusPublished - 2007 Aug

    Keywords

    • 2,4-dinitrofluorobenzene (DNFB)
    • Astragalus membranaceus
    • Atopic dermatitis
    • NC/Nga mice

    ASJC Scopus subject areas

    • Pharmacology
    • Pharmaceutical Science

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