Oral intake of milk ceramides improves skin hydration, elasticity, and wrinkles around the eyes: A 12-week, randomized, double-blind, placebo-controlled trial

Yejin Ahn, Hyung Joo Suh, Ki Bae Hong, Yongjin Choi, Sang Jun Lee, Eun Jin Jung

Research output: Contribution to journalArticlepeer-review

Abstract

Previous studies have shown that milk ceramide (MC) protects against photoaging in ultraviolet B-irradiated mice. Thus, we conducted a 12-week, randomized, double-blind, placebo-controlled clinical study to evaluate the skin improvement efficacy of MC. The participants were women aged 30–65 years with crow's feet who were randomly assigned to receive either MC (600 mg/day) or a placebo for 12 weeks. The participants' degree of wrinkles around eyes was analyzed by expert graders. Additionally, changes in parameters related to skin wrinkling, moisture, and elasticity were measured. In the MC group, the wrinkles and roughness index around the eyes were significantly improved. After 12 weeks, the MC group showed significantly lower transepidermal water loss, and higher skin moisture and elasticity index than the placebo group. No serious adverse events were observed during the study period. Therefore, MC intake is expected to prevent skin aging by improving skin moisture and elasticity and weakening wrinkles.

Original languageEnglish
Article number106008
JournalJournal of Functional Foods
Volume113
DOIs
Publication statusPublished - 2024 Feb

Bibliographical note

Publisher Copyright:
© 2024

Keywords

  • Milk ceramide
  • Skin elasticity
  • Skin hydration
  • Transepidermal water loss
  • Wrinkle

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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